Maprotiline Hydrochloride
Maprotiline Hydrochloride structure
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Common Name | Maprotiline Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 10347-81-6 | Molecular Weight | 313.864 | |
| Density | N/A | Boiling Point | 399.6ºC at 760 mmHg | |
| Molecular Formula | C20H24ClN | Melting Point | 230-232ºC | |
| MSDS | Chinese USA | Flash Point | 187.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.
Sci. Transl. Med. 7 , 290ra89, (2015) Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical ... |
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Mechanism of maprotiline-induced apoptosis: role of [Ca2+](i), ERK, JNK and caspase-3 signaling pathways.
Toxicology 304 , 1-12, (2013) Antidepressants are generally used for treatment of various mood and anxiety disorders. Several studies have shown the anti-tumor and cytotoxic activities of some antidepressants, but the underlying mechanisms were unclear. Maprotiline is a tetracyclic antide... |
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[Pharmacologic correction of psycho-emotive disorders in the rehabilitation of patients after removal of brain tumors].
Vopr. Onkol. 53(6) , 704-10, (2007)
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Further studies on anti-inflammatory activity of maprotiline in carrageenan-induced paw edema in rat.
Int. Immunopharmacol. 15(3) , 505-10, (2013) Antidepressant drugs are commonly used for treatment of different medical disorders besides of psychiatric diseases. Accumulating evidence suggests that antidepressants exhibit anti-inflammatory activity in vivo and in vitro conditions, but the mechanisms of ... |
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Effect of glibenclamide on antinociceptive effects of antidepressants of different classes.
Clinics (Sao. Paulo.) 66(2) , 321-5, (2011) The purpose of this work was to determine whether the intraperitoneal administration of glibenclamide as a K ATP channel blocker could have an effect on the antinociceptive effects of antidepressants with different mechanisms of action.Three antidepressant dr... |
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TMD chronic pain and masseter silent period in psychiatric patients on antidepressive therapy.
J. Oral Rehabil. 35(6) , 424-32, (2008) The aim of the study was to evaluate the long-term effects of antidepressive therapy on chronic pain and related disability, and masseter silent period in psychiatric depressive patients with temporomandibular disorders (TMD). The study included hospitalized ... |
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Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats.
Inflamm. Res. 59(12) , 1053-9, (2010) To explore the site of action of maprotiline, as an atypical antidepressant, on carrageenan-induced paw edema.Male Wistar rats were used.Firstly, the anti-inflammatory effect of systemic maprotiline (12.5, 25 and 50 mg kg(-1)) was assessed using a paw edema m... |
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Antidepressant stimulation of CDP-diacylglycerol synthesis does not require monoamine reuptake inhibition.
BMC Neurosci. 11 , 10, (2010) Recent studies demonstrate that diverse antidepressant agents increase the cellular production of the nucleolipid CDP-diacylglycerol and its synthetic derivative, phosphatidylinositol, in depression-relevant brain regions. Pharmacological blockade of downstre... |
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Gallbladder emptying in patients with major depression: a case series.
Pharmacopsychiatry 44(5) , 165-8, (2011) Although several adverse effects of antidepressants on the gastrointestinal tract have been described (bleeding, constipation, dolichocolon), their influence on gallbladder motility was not investigated.The aim of our study was to investigate the effects of s... |
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Effects of noradrenaline and serotonin reuptake inhibitors on pituitary-adrenocortical and sympatho-adrenomedullar system of adult rats.
Neuro Endocrinol. Lett. 28(5) , 614-20, (2007) To estimate the influence of long-term treatment with noradrenergic and serotonergic reuptake inhibitors on activity of pituitary-adrenocortical and sympatho-adrenomedullar systems in animals, we compared the effects of maprotiline (a selective inhibitor of n... |