ICI 192605
ICI 192605 structure
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Common Name | ICI 192605 | ||
|---|---|---|---|---|
| CAS Number | 117621-64-4 | Molecular Weight | 402.86800 | |
| Density | 1.262 g/cm3 | Boiling Point | 540.1ºC at 760 mmHg | |
| Molecular Formula | C22H23ClO5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 280.4ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Thromboxane and isoprostane share the same prostanoid receptors to increase human placental tone
Placenta 32(12) , 941-8, (2011) As the placenta is devoid of autonomic innervation, umbilical-placental vascular tone should be under the control of tissue and humoral factors. Among the numerous stimuli capable of challenging the placental circulation, we propose that prostanoids could be ... |
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Role of Ca2+ mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle.
Clin. Exp. Allergy 39(2) , 236-45, (2009) Isoprostanes are prostaglandin (PG)-like compounds synthesized by oxidative stress, not by cyclooxygenase, and increase in bronchoalveolar lavage fluid of patients with asthma. The airway inflammation implicated in this disease may be amplified by oxidants. A... |
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Endothelial thromboxane production plays a role in the contraction caused by 5-hydroxytryptamine in rat basilar arteries.
Eur. J. Pharmacol. 243(2) , 193-9, (1993) The goal of the present study was to characterize the role of the endothelium in the 5-hydroxytryptamine (5-HT)-induced contraction of the rat basilar artery. Rat basilar artery segments were mounted in myographs to study their isometric tension development. ... |
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Bradykinin-induced release of thromboxane B2 into bronchoalveolar lavage fluid of guinea pigs: relationship to airflow obstruction.
Eur. J. Pharmacol. 280(3) , 293-9, (1995) The aim of this study was to evaluate the role of thromboxane A2 in bradykinin-induced airflow obstruction in guinea pig in vivo. Airway insufflation pressure (Pi) was measured to assess airflow obstruction and the thromboxane B2 (a stable metabolite of throm... |
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Combined administration of 5-HT2 and thromboxane A2 antagonists: effects on platelet aggregation and isolated cardiac muscle.
Br. J. Pharmacol. 121(5) , 875-82, (1997) 1. To investigate possible mechanisms underlying the ability of combined administration of a 5-hydroxytryptamine2 (5-HT2) antagonist and a thromboxane A2 antagonist to reduce reperfusion-induced arrhythmias, the effects of these drugs alone and in combination... |
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Effects of eicosanoids on parameters in isolated rat hepatocytes and isolated rat hepatocyte couplets: protective effects of eicosanoid receptor antagonists.
J. Lipid Mediat. Cell Signal. 15(3) , 249-54, (1997) A number of eicosanoids caused plasma membrane blebbing in hepatocytes and this could be inhibited in a dose-dependent fashion by the receptor antagonists AH6809 and ICI 192605. The pattern of effectiveness of eicosanoids interfering with canalicular vacuole ... |
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Endothelium-dependent vasorelaxation induced by L-carnitine in isolated aorta from normotensive and hypertensive rats.
J. Pharm. Pharmacol. 54(10) , 1423-7, (2002) The aim of this work was to investigate the mechanism of the vasodilatory effect induced by L-carnitine. Relaxation produced by L-carnitine was studied in rat aortic rings with and without functional endothelium, pre-contracted with phenylephrine by adding cu... |
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Vasoconstrictor effects of 8-iso-prostaglandin E2 and 8-iso-prostaglandin F(2alpha) on human umbilical vein.
Eur. J. Pharmacol. 499(1-2) , 189-95, (2004) The present study was undertaken to determine whether 8-iso-prostaglandin E2 and 8-iso-prostaglandin F(2alpha) posses contractile action on human umbilical vein and to evaluate the possible involvement of prostanoid TP receptors in this effect. Human umbilica... |
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Platelet reactivity in vitro in relation to thromboxane in healthy pregnancy.
Thromb. Haemost. 75(2) , 346-51, (1996) There is substantial evidence of increased platelet reactivity in vivo and in vitro during pregnancy. Previous in vitro studies suggest that platelets from pregnant women show increased sensitivity to agonists, the response to which has a thromboxane dependen... |
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Contraction to endothelin-1 in pulmonary arteries from endotoxin-treated rats is modulated by endothelium.
Am. J. Physiol. 268(6 Pt 2) , H2260-6, (1995) Sepsis is characterized by hyporesponsiveness of vascular smooth muscle to pressor agents. Levels of the potent vasoconstrictor, endothelin-1 (ET-1), are elevated in animal models of sepsis and in patients. This study assesses the contractile response of pulm... |