ICI 192605
Modify Date: 2024-01-02 23:18:14
ICI 192605 structure
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Common Name | ICI 192605 | ||
|---|---|---|---|---|
| CAS Number | 117621-64-4 | Molecular Weight | 402.86800 | |
| Density | 1.262 g/cm3 | Boiling Point | 540.1ºC at 760 mmHg | |
| Molecular Formula | C22H23ClO5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 280.4ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of ICI 192605ICI 192605 is a potent TXA2R (thromboxane A2 receptor) antagonist as cell signaling prostaglandin. ICI 192605 blocks contraction of isolated guinea pig trachea induced by U-46619[1]. |
| Name | (Z)-6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | ICI 192605 is a potent TXA2R (thromboxane A2 receptor) antagonist as cell signaling prostaglandin. ICI 192605 blocks contraction of isolated guinea pig trachea induced by U-46619[1]. |
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| Related Catalog | |
| References |
| Density | 1.262 g/cm3 |
|---|---|
| Boiling Point | 540.1ºC at 760 mmHg |
| Molecular Formula | C22H23ClO5 |
| Molecular Weight | 402.86800 |
| Flash Point | 280.4ºC |
| Exact Mass | 402.12300 |
| PSA | 75.99000 |
| LogP | 5.25960 |
| Vapour Pressure | 1.7E-12mmHg at 25°C |
| Index of Refraction | 1.583 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H410 |
| Precautionary Statements | P273-P501 |
| RIDADR | UN 3077 9 / PGIII |
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Thromboxane and isoprostane share the same prostanoid receptors to increase human placental tone
Placenta 32(12) , 941-8, (2011) As the placenta is devoid of autonomic innervation, umbilical-placental vascular tone should be under the control of tissue and humoral factors. Among the numerous stimuli capable of challenging the p... |
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Role of Ca2+ mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle.
Clin. Exp. Allergy 39(2) , 236-45, (2009) Isoprostanes are prostaglandin (PG)-like compounds synthesized by oxidative stress, not by cyclooxygenase, and increase in bronchoalveolar lavage fluid of patients with asthma. The airway inflammation... |
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Endothelial thromboxane production plays a role in the contraction caused by 5-hydroxytryptamine in rat basilar arteries.
Eur. J. Pharmacol. 243(2) , 193-9, (1993) The goal of the present study was to characterize the role of the endothelium in the 5-hydroxytryptamine (5-HT)-induced contraction of the rat basilar artery. Rat basilar artery segments were mounted ... |
| 6-(2-(2-Chlorophenyl-4-hydroxyphenyl)-1,3-dioxan-5-yl)hexenoic acid |
| 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid |
| 4-Hexenoic acid,6-(2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl)-,(2alpha,4alpha,5alpha(Z)) |
| (4Z)-rel |
| 4(Z)-6-(2,4,5-cis)-[(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hexenoic acid |
| (Z)-6-(-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl)hex-4-enoic acid |
| (4Z)-6-<(2RS,4RS,5SR)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl>hex-4-enoic acid |