121264-04-8

121264-04-8 structure

Name: ICI 204,448 hydrochloride
Chemical Name: 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenoxy]acetic acid,hydrochloride
CAS Number: 121264-04-8
Molecular Formula: C₂₃H₂₇Cl₃N₂O₄
Molecular Weight: 501.83
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2018-12-22 09:03:50
Modify Date: 2025-08-27 09:05:19
ICI-204448 is a κ-opioid agonist with limited access to the CNS, ICI-204448 can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes[1].

Name	2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenoxy]acetic acid,hydrochloride
Synonyms	MFCD00153814 ICI 204,448 hydrochloride

Description	ICI-204448 is a κ-opioid agonist with limited access to the CNS, ICI-204448 can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
References	[1]. J S Shaw, et, al. ICI 204448: a kappa-opioid agonist with limited access to the CNS. Br J Pharmacol. 1989, 96, 4.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3