7-Deazaadenosine(Tubercidin)
7-Deazaadenosine(Tubercidin) structure
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Common Name | 7-Deazaadenosine(Tubercidin) | ||
|---|---|---|---|---|
| CAS Number | 69-33-0 | Molecular Weight | 266.253 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 648.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C11H14N4O4 | Melting Point | 247-248 °C (decomp) | |
| MSDS | Chinese USA | Flash Point | 346.2±31.5 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Plasmodium falciparum: the potential of the cancer chemotherapeutic agent cisplatin and its analogues as anti-malarials.
Exp. Parasitol. 132(4) , 440-3, (2012) The anti-malarial activity of the cancer chemotherapeutic agent cisplatin and cisplatin analogues was determined in Plasmodium falciparum. The cisplatin analogues included DNA-targeted acridine-tethered platinum compounds, carboplatin and transplatin. A [(3)H... |
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Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9.
Mol. Cancer Ther. 11(11) , 2321-30, (2012) Despite significant treatment advances over the past decade, multiple myeloma (MM) remains largely incurable. In this study we found that MM cells were remarkably sensitive to the death-inducing effects of a new class of sangivamycin-like molecules (SLM). A p... |
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Insights into phosphate cooperativity and influence of substrate modifications on binding and catalysis of hexameric purine nucleoside phosphorylases.
PLoS ONE 7(9) , e44282, (2012) The hexameric purine nucleoside phosphorylase from Bacillus subtilis (BsPNP233) displays great potential to produce nucleoside analogues in industry and can be exploited in the development of new anti-tumor gene therapies. In order to provide structural basis... |
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Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture.
Antimicrob. Agents Chemother. 54 , 5329-36, (2010) Bacillus anthracis, the etiological agent of anthrax, has a dormant stage in its life cycle known as the endospore. When conditions become favorable, spores germinate and transform into vegetative bacteria. In inhalational anthrax, the most fatal manifestatio... |
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Pharmacologic correction of dominant-negative GH1 deficiency causing mutations.
Clin. Transl. Sci. 4(3) , 175-9, (2011) Dominant-negative growth hormone gene (GH1) mutations cause familial isolated growth hormone deficiency type II (IGHD II), which is characterized by GH deficiency, occasional multiple anterior pituitary hormone deficiencies, and anterior pituitary hypoplasia.... |
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PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine.
Mol. Pain 7 , 80, (2011) Prostatic acid phosphatase (PAP) and ecto-5'-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main ectonucleotidases that generat... |
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Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation.
J. Cell Biol. 199(2) , 251-68, (2012) Haspin phosphorylates histone H3 at threonine-3 (H3T3ph), providing a docking site for the Aurora B complex at centromeres. Aurora B functions to correct improper kinetochore-microtubule attachments and alert the spindle checkpoint to the presence of misalign... |
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A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B.
J. Cell Biol. 199(2) , 269-84, (2012) By phosphorylating Thr3 of histone H3, Haspin promotes centromeric recruitment of the chromosome passenger complex (CPC) during mitosis. Aurora B kinase, a CPC subunit, sustains chromosome bi-orientation and the spindle assembly checkpoint (SAC). Here, we cha... |
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A general framework for inhibitor resistance in protein kinases.
Chem. Biol. 18(8) , 966-75, (2011) Protein kinases control virtually every aspect of normal and pathological cell physiology and are considered ideal targets for drug discovery. Most kinase inhibitors target the ATP binding site and interact with residue of a hinge loop connecting the small an... |
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RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
Cell 155(4) , 793-806, (2013) The eukaryotic biological clock involves a negative transcription-translation feedback loop in which clock genes regulate their own transcription and that of output genes of metabolic significance. While around 10% of the liver transcriptome is rhythmic, only... |