Aminoacetonitrile
Aminoacetonitrile structure
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Common Name | Aminoacetonitrile | ||
|---|---|---|---|---|
| CAS Number | 540-61-4 | Molecular Weight | 56.067 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 164.2±23.0 °C at 760 mmHg | |
| Molecular Formula | C2H4N2 | Melting Point | 101°C (lit.) | |
| MSDS | USA | Flash Point | 53.1±22.6 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Monepantel irreversibly binds to and opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 receptors.
Mol. Pharmacol. 87(1) , 96-102, (2015) Monepantel is a recently developed anthelmintic with a novel mode of action. Parasitic nematodes with reduced sensitivity to monepantel have led to the identification of MPTL-1, a ligand-gated ion-channel subunit of the parasitic nematode Haemonchus contortus... |
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Inhibition of ERK1/2 signaling prevents epileptiform behavior in rats prone to audiogenic seizures.
J. Neurochem. 132(2) , 218-29, (2015) It has recently been proposed that extracellular signal-regulated kinases 1 and 2 (ERK1/2) are one of the factors mediating seizure development. We hypothesized that inhibition of ERK1/2 activity could prevent audiogenic seizures by altering GABA and glutamat... |
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Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1.
Neuropharmacology 72 , 197-203, (2013) The ribosomal protein S6 (rpS6) is a component of the small 40S ribosomal subunit, involved in multiple physiological functions. Here, we examined the effects produced by haloperidol, a typical antipsychotic drug, on the phosphorylation of rpS6 at Ser240/244 ... |
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[New drugs for horses and production animals in 2010].
Tierarztl. Prax. Ausg. G. Grosstiere. Nutztiere. 39(6) , 384-90, (2011) In 2010, three new active pharmaceutical ingredients were released on the German market for horses and food-producing animals. These were gamithromycin (Zactran®), a new macrolide antibiotic, Monepantel (Zolvix®), a broad spectrum anthelmintic with a novel me... |
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Efficacy of monepantel, derquantel and abamectin against adult stages of a multi-resistant Haemonchus contortus isolate.
Parasitol. Res. 111(5) , 2205-7, (2012) Drug resistance in gastrointestinal nematodes is a severe problem for sheep farmers. With the recent introduction of monepantel (Zolvix®) and of derquantel plus abamectin (Startect®) in New Zealand, two new anthelmintic classes will be available to control ga... |
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The comparative efficacy of abamectin, monepantel and an abamectin/derquantel combination against fourth-stage larvae of a macrocyclic lactone-resistant Teladorsagia spp. isolate infecting sheep
Vet. Parasitol. 188(1-2) , 190-3, (2012) Anthelmintic resistance by gastrointestinal nematodes of sheep continues to be an issue of global interest. While the recent introduction in some countries of one or two new anthelmintic classes (amino-acetonitrile derivatives [AAD] and spiroindoles [SI]) has... |
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The MEK inhibitor SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study.
Psychopharmacology 216(1) , 63-73, (2011) Recent evidence involves extracellular signal-regulated kinase (ERK) in positive motivational properties of drugs as determined by conditioned place preference but, to date, its role in conditioned place aversion (CPA) still awaits to be fully characterized.T... |
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Mitogen-activated protein kinase in the amygdala plays a critical role in lithium chloride-induced taste aversion learning.
Neurobiol. Learn. Mem. 97(1) , 132-9, (2012) The intracellular mitogen-activated protein kinase (MAPK) pathway in the brain is necessary for the formation of a variety of memories including conditioned taste aversion (CTA) learning. However, the functional role of MAPK activation in the amygdala during ... |
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Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome.
J. Neurochem. 121(4) , 672-9, (2012) Fragile X syndrome (FXS) is a developmental disorder caused by the loss of Fragile X Mental Retardation 1 (FMR1) gene function because of a CGG repeat expansion (> 200 repeats) in the gene. The molecular mechanism(s) linking loss of FMR1 function to the molec... |
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The efficacy of monepantel against naturally acquired inhibited and developing fourth-stage larvae of Teladorsagia circumcincta in sheep in the United Kingdom.
Vet. Parasitol. 186(3-4) , 528-31, (2012) The inhibition of Teladorsagia and other nematode genera at the early fourth-stage is a biological process that allows the parasites to survive in their host in a dormant state when prevailing conditions may otherwise kill them or prevent their progeny from s... |