|CAS Number||540-61-4||Molecular Weight||56.067|
|Density||1.0±0.1 g/cm3||Boiling Point||164.2±23.0 °C at 760 mmHg|
|Molecular Formula||C2H4N2||Melting Point||N/A|
|MSDS||USA||Flash Point||53.1±22.6 °C|
|Boiling Point||164.2±23.0 °C at 760 mmHg|
|Flash Point||53.1±22.6 °C|
|Vapour Pressure||2.0±0.3 mmHg at 25°C|
|Index of Refraction||1.418|
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
|Personal Protective Equipment||Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter|
|Hazard Codes||Xn: Harmful;|
|RIDADR||NA 1993 / PGIII|
|Summary||HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%|
Monepantel irreversibly binds to and opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 receptors.
Mol. Pharmacol. 87(1) , 96-102, (2015)
Monepantel is a recently developed anthelmintic with a novel mode of action. Parasitic nematodes with reduced sensitivity to monepantel have led to the identification of MPTL-1, a ligand-gated ion-cha...
Inhibition of ERK1/2 signaling prevents epileptiform behavior in rats prone to audiogenic seizures.
J. Neurochem. 132(2) , 218-29, (2015)
It has recently been proposed that extracellular signal-regulated kinases 1 and 2 (ERK1/2) are one of the factors mediating seizure development. We hypothesized that inhibition of ERK1/2 activity coul...
Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1.
Neuropharmacology 72 , 197-203, (2013)
The ribosomal protein S6 (rpS6) is a component of the small 40S ribosomal subunit, involved in multiple physiological functions. Here, we examined the effects produced by haloperidol, a typical antips...