4-Bromo-2-chloro-1-fluorobenzene

4-Bromo-2-chloro-1-fluorobenzene Structure
4-Bromo-2-chloro-1-fluorobenzene structure
Common Name 4-Bromo-2-chloro-1-fluorobenzene
CAS Number 60811-21-4 Molecular Weight 209.443
Density 1.7±0.1 g/cm3 Boiling Point 196.4±20.0 °C at 760 mmHg
Molecular Formula C6H3BrClF Melting Point N/A
MSDS Chinese USA Flash Point 72.6±21.8 °C
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning

Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor.

Chemistry 20(1) , 263-71, (2014)

Conducting low-temperature organometallic reactions under continuous flow conditions offers the potential to more accurately control exotherms and thus provide more reproducible and scalable processes. Herein, progress towards this goal with regards to the li...

Efficient synthesis of a GABA A alpha2,3-selective allosteric modulator via a sequential Pd-catalyzed cross-coupling approach.

J. Org. Chem. 70(15) , 6034-6039, (2005)

A practical synthesis of 2-[3-(4-fluoro-3-pyridin-3-yl-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-propan-2-ol (1), an oral GABA(A) alpha(2/3)-selective agonist, is described. The five-step process, which afforded 1 in 40% overall yield, included imidazopyrimidine ...