D-(-)-Morphine
D-(-)-Morphine structure
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Common Name | D-(-)-Morphine | ||
|---|---|---|---|---|
| CAS Number | 57-27-2 | Molecular Weight | 285.338 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 476.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H19NO3 | Melting Point | 255ºC | |
| MSDS | N/A | Flash Point | 241.8±28.7 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Catalytic enantioselective synthesis of quaternary carbon stereocentres.
Nature 516(7530) , 181-91, (2014) Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single stereoi... |
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Enteral absorption and haemodynamic response of clonidine in infants post-cardiac surgery.
Br. J. Anaesth. 113(6) , 964-9, (2014) Clonidine is a useful analgesic-sedative agent; however, few data exist regarding its use in infants after congenital heart disease surgery. We thus aimed to assess the absorption and safety of enterally administered clonidine in this setting.Sixteen infants ... |
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Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy.
Life Sci. 92(23) , 1138-44, (2013) In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between noradrenaline (NA) release in the LC and efficacy of analge... |
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Hypernociceptive responses following the intratibial inoculation of RM1 prostate cancer cells in mice.
Prostate 75(1) , 70-83, (2015) Pain due to bone metastases of prostatic origin is a relevant clinical issue. We study here the nociceptive responses obtained in mice receiving the intratibial inoculation of RM1 prostate cancer cells.10(2) -10(5) RM1 cells were inoculated to C57BL/6 mice an... |
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TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
J. Neurosci. 34(15) , 5385-95, (2014) Transforming growth factor-β1 (TGF-β1) protects against neuroinflammatory events underlying neuropathic pain. TGF-β signaling enhancement is a phenotypic characteristic of mice lacking the TGF-β pseudoreceptor BAMBI (BMP and activin membrane-bound inhibitor),... |
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Analgesic efficacy of continuous intravenous magnesium infusion as an adjuvant to morphine for postoperative analgesia: a systematic review and meta-analysis.
Middle East J. Anesthesiol. 22(1) , 11-20, (2013) The efficacy of perioperative intravenous magnesium administration on postoperative opioid use, opioid-related side effects (e.g., nausea and vomiting) and pain are uncertain, as randomized controlled trials on this topic have reported disparate results. The ... |
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Morphine glucuronidation increases its analgesic effect in guinea pigs.
Life Sci. 109(2) , 104-10, (2014) Morphine is extensively metabolized to neurotoxic morphine-3-glucuronide (M3G) and opioid agonist morphine-6-glucuronide (M6G). Due to these different roles, interindividual variability and co-administration of drugs that interfere with metabolism may affect ... |
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Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors.
J. Neurosci. 33(18) , 7728-41, (2013) Baseline and nicotine-modulated behaviors were assessed in mice harboring a null mutant allele of the nicotinic acetylcholine receptor (nAChR) subunit gene α2 (Chrna2). Homozygous Chrna2(-/-) mice are viable, show expected sex and Mendelian genotype ratios, a... |
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Naloxone blocks the beneficial effects of aqueous extract of Murraya koenigii (L.) Spreng leaves in models of pain.
Eur. Rev. Med. Pharmacol. Sci. 17(13) , 1748-51, (2013) This study investigated the antinociceptive effects of aqueous extract of Murraya koenigii (AEMK) leaves (200, 400 and 800 mg/kg, orally) on animal models of acute and persistent pain and its modulation by naloxone.Antinociceptive effects were assessed using ... |
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The association between sedation practices and duration of mechanical ventilation in intensive care.
Anaesth. Intensive Care 41(3) , 311-5, (2013) Choice of sedation agent may influence duration of mechanical ventilation in the intensive care unit (ICU). We conducted a retrospective observational analysis of 2102 consecutive mechanically ventilated ICU patients over an eight-year period at a Melbourne m... |