NAADP tetrasodium salt
NAADP tetrasodium salt structure
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Common Name | NAADP tetrasodium salt | ||
|---|---|---|---|---|
| CAS Number | 5502-96-5 | Molecular Weight | 744.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H27N6O18P3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Involvement of actin filament in the generation of Ca2+ mobilizing messengers in glucose-induced Ca2+ signaling in pancreatic β-cells.
Islets 4(2) , 145-51, (2012) Glucose is a metabolic regulator of insulin secretion from pancreatic β-cells, which is regulated by intracellular Ca(2+) signaling. We and others previously demonstrated that glucose activates CD38/ADP-ribosyl cyclase (ADPR-cyclase) to produce two Ca(2+) sec... |
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The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.
Biochem. J. 453(1) , 147-51, (2013) TPCs (two-pore channels) are NAADP (nicotinic acid-adenine dinucleotide phosphate)-sensitive Ca2+-permeable ion channels expressed on acidic organelles. In the present study we show that deletion of the N-terminal region redirects TPC1 to the ER (endoplasmic ... |
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Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation.
J. Biol. Chem. 288(22) , 16017-30, (2013) Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-releasing second messenger known to date. Here, we report a new role for NAADP in arrhythmogenic Ca(2+) release in cardiac myocytes evoked by β-adrenergic stimulation. Infusion of... |
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Two-pore channels function in calcium regulation in sea star oocytes and embryos.
Development 141(23) , 4598-609, (2014) Egg activation at fertilization is an excellent process for studying calcium regulation. Nicotinic acid adenine dinucleotide-phosphate (NAADP), a potent calcium messenger, is able to trigger calcium release, likely through two-pore channels (TPCs). Concomitan... |
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N-terminal tagging of two-pore channels interferes with NAADP action.
Biochem. J. 453(1) , e1-2, (2013) NAADP (nicotinic acid-adenine dinucleotide phosphate) is the most potent Ca2+-releasing second messenger known to date. Since its discovery in 1995 identifying the NAADP receptor protein/Ca2+ channel has been a major persuit of the Ca2+ signalling community. ... |
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Extracellular NAADP affords cardioprotection against ischemia and reperfusion injury and involves the P2Y11-like receptor
Biochem. Biophys. Res. Commun. 434(3) , 428-33, (2013) • Extracellular NAADP promotes cardiac preconditioning via the P2Y11-like receptors. • P2Y11-like receptors are able to induce prosurvival kinase activation in rat cardiomyocyte. • NAADP is released during ischemia suggesting a paracrine survival role. |
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Characterization of NAADP-mediated calcium signaling in human spermatozoa.
Biochem. Biophys. Res. Commun. 443(2) , 531-6, (2014) Ca(2+) signaling in spermatozoa plays a crucial role during processes such as capacitation and release of the acrosome, but the underlying molecular mechanisms still remain unclear. Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+)-rele... |
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Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes
Biochim. Biophys. Acta 1833(12) , 3228-36, (2013) Autophagic flux is an important process during autophagy maturation in coronary arterial myocytes (CAMs). Here, we defined the role and molecular mechanism of the motor protein dynein in the regulation of autophagic flux in CAMs. In mouse CAMs, dynein protein... |
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Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes.
J. Biol. Chem. 288(49) , 35548-58, (2013) Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger for mobilizing Ca(2+) from intracellular stores in various cell types. Extracellular application of NAADP has been shown to elicit intracellular Ca(2+) signals, indicating that it is ... |
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LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy.
Autophagy 8(4) , 692-3, (2012) Alterations in autophagy are thought to underlie various neurodegenerative diseases including Parkinson disease (PD). Previous studies have indicated that the PD gene leucine rich repeat kinase 2 (LRRK2) is involved in this process, but its mechanism of actio... |