Autophagy 2012-04-01

LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy.

Patricia Gómez-Suaga, Sabine Hilfiker

Index: Autophagy 8(4) , 692-3, (2012)

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Abstract

Alterations in autophagy are thought to underlie various neurodegenerative diseases including Parkinson disease (PD). Previous studies have indicated that the PD gene leucine rich repeat kinase 2 (LRRK2) is involved in this process, but its mechanism of action has remained unknown. Our recent work describes how LRRK2 acts through calcium-mediated events originating from acidic stores to regulate autophagy and cell survival, which may give rise to novel therapeutic strategies.