2,4-Dihydroxy-5-nitropyrimidine
2,4-Dihydroxy-5-nitropyrimidine structure
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Common Name | 2,4-Dihydroxy-5-nitropyrimidine | ||
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| CAS Number | 611-08-5 | Molecular Weight | 157.084 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 453.3±48.0 °C at 760 mmHg | |
| Molecular Formula | C4H3N3O4 | Melting Point | >300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 227.9±29.6 °C | |
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Phenobarbital induction and chemical synergism demonstrate the role of UDP-glucuronosyltransferases in detoxification of naphthalophos by Haemonchus contortus larvae.
Antimicrob. Agents Chemother. 58(12) , 7475-83, (2014) We used an enzyme induction approach to study the role of detoxification enzymes in the interaction of the anthelmintic compound naphthalophos with Haemonchus contortus larvae. Larvae were treated with the barbiturate phenobarbital, which is known to induce t... |
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Inhibition of UDP-glucuronyltransferase activity in rat liver microsomes by pyrimidine derivatives.
Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. 112(3) , 321-5, (1995) Thirty-one differently substituted pyrimidine bases were tested for their inhibitory effect on the glucuronidation of 4-nitrophenol and phenolphthalein by rat liver microsomes. 5-Nitrouracil (compound 1) and its isomer 4,6-dihydroxy-5-nitropyrimidine (compoun... |
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Thymidine phosphorylase inhibitors with a homophthalimide skeleton.
Biol. Pharm. Bull. 24(7) , 860-2, (2001) Several N-phenylhomophthalimide derivatives were prepared and their inhibitory activity on thymidine phosphorylase/ platelet-derived endothelial cell growth factor (TP/PD-ECGF) was assessed. Among them, 2-(2,6-diethylphenyl)-7-nitro-1,2,3,4-tetrahydroisoquino... |
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The significance of 3H-thymidine degradation in cell culture experiments with special reference to rheumatoid arthritis.
APMIS 96(9) , 768-72, (1988) The degradation of 3H-thymidine under various cell culture conditions was analysed. It was found that a half of 3H-thymidine was degraded to 3H-thymine during 24 hours in PHA stimulation of blood lymphocytes. A control culture in which PHA was not added also ... |
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[Conformational analysis of 5-substituted uracil].
Biofizika 34(5) , 753-7, (1989) The high-resolution IR-spectra of 5-nitrouracil and 5-bromouracil isolated in Ar matrices at 11 K were obtained for the first time. The conformational structure of uracil 5-substituents--thymine, 5-bromouracil, 5-nitrouracil--is calculated by the molecular me... |
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Catabolism of 5-fluoro-2'-deoxyuridine by isolated rat intestinal epithelial cells.
Proc. Soc. Exp. Biol. Med. 189(3) , 353-61, (1988) The kinetics of conversion of 5-fluoro-2'-deoxyuridine (FdUrd) to 5-fluorouracil (FUra) by isolated rat intestinal epithelial cells was investigated. Also, the effects of potential inhibitors of this reaction, which is catalyzed by uridine phosphorylase and t... |
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Interaction of tRNA (uracil-5-)-methyltransferase with NO2Ura-tRNA.
Nucleic Acids Res. 24(6) , 1059-64, (1996) tRNA in which uracil is completely replaced by 5-nitro-uracil was prepared by substituting 5-nitro-UTP for UTP in an in vitro transcription reaction. The rationale was that the 5-nitro substituent activates the 6-carbon of the Ura heterocycle towards nucleoph... |
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Radioactivity-based and spectrophotometric assays for isoorotate decarboxylase: identification of the thymidine salvage pathway in lower eukaryotes.
Anal. Biochem. 266(1) , 85-92, (1999) A few organisms, notably some fungi, have the ability to metabolize thymidine to uracil, thus conserving the pyrimidine ring for subsequent metabolic use. Neurospora crassa possesses this pathway, termed the thymidine salvage pathway, and can utilize thymidin... |