Myosmine
Myosmine structure
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Common Name | Myosmine | ||
|---|---|---|---|---|
| CAS Number | 532-12-7 | Molecular Weight | 146.189 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 244.7±22.0 °C at 760 mmHg | |
| Molecular Formula | C9H10N2 | Melting Point | 42-44°C | |
| MSDS | Chinese USA | Flash Point | 101.8±22.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A reversed-phase HPLC-UV method developed and validated for simultaneous quantification of six alkaloids from Nicotiana spp.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 997 , 142-5, (2015) A reversed-phase HPLC-UV method was developed, optimized, and validated for the separation and quantitation of six target alkaloids from leaves of Nicotiana species (nicotine, nornicotine, anatabine, anabasine, myosmine, and cotinine). A bidentate reversed-ph... |
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Effects of nicotine and minor tobacco alkaloids on intracranial-self-stimulation in rats.
Drug Alcohol Depend. 153 , 330-4, (2015) While nicotine is the primary addictive compound in tobacco, other tobacco constituents including minor alkaloids (e.g., nornicotine, anabasine) may also contribute to tobacco addiction by mimicking or enhancing the effects of nicotine. Further evaluating the... |
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Low-dose nicotine self-administration is reduced in adult male rats naïve to high doses of nicotine: implications for nicotine product standards.
Exp. Clin. Psychopharmacol. 22(5) , 453-9, (2014) Product standards that greatly reduce the content of nicotine within cigarettes may result in improved public health. The study presented here used an animal model to investigate whether individuals who start smoking after implementation of regulation may be ... |
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A novel pathway for nicotine degradation by Aspergillus oryzae 112822 isolated from tobacco leaves.
Res. Microbiol. 161(7) , 626-33, (2010) An efficient nicotine-degrading fungus was isolated from tobacco leaves and identified as Aspergillus oryzae 112822 based on morphological characteristics and sequence analysis of 18S rDNA, 5.8S rDNA and the internal transcribed spacer (5.8S-ITS region). When... |
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Evaluation of the mutagenic effects of myosmine in human lymphocytes using theHPRTgene mutation assay
Food Chem. Toxicol. 47(1) , 237-41, (2009) The minor tobacco alkaloid myosmine is implicated in DNA damage through pyridyloxobutylation similar to the tobacco-specific nitrosamines (TSNA). In contrast to TSNA, occurrence of myosmine is not restricted to tobacco. Myosmine is genotoxic to human cells in... |
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Effects of myosmine on antioxidative defence in rat liver.
Arh. Hig. Rada Toksikol. 63(1) , 7-14, (2012) Myosmine [3-(1-pyrrolin-2-yl) pyridine] is an alkaloid structurally similar to nicotine, which is known to induce oxidative stress. In this study we investigated the effects of myosmine on enzymatic and non-enzymatic antioxidative defence in rat liver. Wistar... |
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Sequential preconcentration by coupling of field amplified sample injection with pseudo isotachophoresis-acid stacking for analysis of alkaloids in capillary electrophoresis.
Anal. Bioanal. Chem 390(6) , 1645-52, (2008) A novel on-column sequential preconcentration method based on the combination of field-amplified sample injection induced by acetonitrile and pseudo isotachophoresis (ITP)-acid stacking is developed for simply but efficiently concentrating alkaloid cations in... |
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Distribution of exposure concentrations and doses for constituents of environmental tobacco smoke.
Risk Anal. 19(3) , 375-90, (1999) The ultimate goal of the research reported in this series of three articles is to derive distributions of doses of selected environmental tobacco smoke (ETS)-related chemicals for nonsmoking workers. This analysis uses data from the 16-City Study collected wi... |
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Nicotine demethylation in Nicotiana cell suspension cultures: N'-formylnornicotine is not involved.
Phytochemistry 66(20) , 2432-40, (2005) Nicotine or nornicotine enriched with stable isotopes in either the N'-methyl group or the pyrrolidine-N were fed to Nicotiana plumbaginifolia suspension cell cultures that do not form endogenous nicotine. The metabolism of these compounds was investigated by... |
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Analysis of myosmine, cotinine and nicotine in human toenail, plasma and saliva.
Biomarkers 14(5) , 278-84, (2009) Myosmine is a minor tobacco alkaloid with widespread occurrence in the human diet. Myosmine is genotoxic in human cells and is readily nitrosated and peroxidated yielding reactive intermediates with carcinogenic potential. For biomonitoring of short-term and ... |