Cortisone
Cortisone structure
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Common Name | Cortisone | ||
|---|---|---|---|---|
| CAS Number | 53-06-5 | Molecular Weight | 360.444 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 567.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H28O5 | Melting Point | 223-228 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 311.2±26.6 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Microwave-assisted derivatization: application to steroid profiling by gas chromatography/mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 960 , 8-13, (2014) Gas chromatography-mass spectrometry (GC-MS) remains as the gold-standard technique for the study of the steroid metabolome. A main limitation is the need of performing a derivatization step since incubation with strong silylations agents for long periods of ... |
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Catalytic enantioselective synthesis of quaternary carbon stereocentres.
Nature 516(7530) , 181-91, (2014) Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single stereoi... |
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Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS.
J. Mass Spectrom. 50(3) , 633-42, (2015) Glucocorticosteroids are prohibited in sports when used by systemic administrations (e.g. oral), whereas they are allowed using other administration ways. Strategies to discriminate between administrations routes have to be developed by doping control laborat... |
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A comprehensive study for the validation of a LC-MS/MS method for the determination of free and total forms of urinary cortisol and its metabolites.
J. Pharm. Biomed. Anal. 94 , 203-9, (2014) Several pathological conditions can be related to the alteration of the urinary levels of cortisol (F) and its metabolites. The determination of each of them in the free and free plus conjugated form can provide a deeper insight into the impaired activity of ... |
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Carbonyl reduction of triadimefon by human and rodent 11β-hydroxysteroid dehydrogenase 1.
Biochem. Pharmacol. 85(9) , 1370-8, (2013) 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the conversion of inactive 11-oxo glucocorticoids (endogenous cortisone, 11-dehydrocorticosterone and synthetic prednisone) to their potent 11β-hydroxyl forms (cortisol, corticosterone and prednisolone).... |
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Cortisone and hydrocortisone inhibit human Kv1.3 activity in a non-genomic manner.
Naunyn Schmiedebergs Arch. Pharmacol. 388 , 653-61, (2015) Glucocorticoids are hormones released in response to stress that are involved in various physiological processes including immune functions. One immune-modulating mechanism is achieved by the Kv1.3 voltage-dependent potassium channel, which is expressed highl... |
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FOXO1 is required for binding of PR on IRF4, novel transcriptional regulator of endometrial stromal decidualization.
Mol. Endocrinol. 29(3) , 421-33, (2015) The forkhead box O1A (FOXO1) is an early-induced target of the protein kinase A pathway during the decidualization of human endometrial stromal cells (HESCs). In this study we identified the cistrome and transcriptome of FOXO1 and its role as a transcriptiona... |
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Detection of 11 beta-hydroxysteroid dehydrogenase type 1, the glucocorticoid and mineralocorticoid receptor in various adipose tissue depots of dairy cows supplemented with conjugated linoleic acids.
J. Anim. Physiol. Anim. Nutr. (Berl.) 99 , 950-61, (2015) Early lactating cows mobilize adipose tissue (AT) to provide energy for milk yield and maintenance and are susceptible to metabolic disorders and impaired immune response. Conjugated linoleic acids (CLA), mainly the trans-10, cis-12 isomer, reduce milk fat sy... |
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Characterization of large surface area polymer monoliths and their utility for rapid, selective solid phase extraction for improved sample clean up.
J. Chromatogr. A. 1410 , 9-18, (2015) While polymer monoliths are widely described for solid phase extraction (SPE), appropriate characterization is rarely provided to unravel the links between physical characteristics and observed advantages and disadvantages. Two known approaches to fabricate l... |
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Simultaneous assessment of protein heterogeneity and affinity by capillary electrophoresis-mass spectrometry.
Anal. Chem. 87 , 8781-8, (2015) Most conventional analytical tools for the assessment of protein-protein interactions yield information on the bulk sample. By employing the efficient separation of intact proteins, affinity capillary electrophoresis (ACE) can measure the interaction of compo... |