N-Nitroso-N-methylurea
N-Nitroso-N-methylurea structure
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Common Name | N-Nitroso-N-methylurea | ||
|---|---|---|---|---|
| CAS Number | 684-93-5 | Molecular Weight | 103.080 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 164.3±23.0 °C at 760 mmHg | |
| Molecular Formula | C2H5N3O2 | Melting Point | 119-124°C | |
| MSDS | Chinese USA | Flash Point | 53.1±22.6 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.
Arch. Toxicol. 89 , 2413-27, (2015) Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicating factor is that non-genotoxic carcinogens act through seve... |
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Optimal dose selection of N-methyl-N-nitrosourea for the rat comet assay to evaluate DNA damage in organs with different susceptibility to cytotoxicity.
Mutat. Res. Genet. Toxicol. Environ. Mutagen. 786-788 , 129-36, (2015) The in vivo rodent alkaline comet assay (comet assay) is a promising technique to evaluate DNA damage in vivo. However, there is no agreement on a method to evaluate DNA damage in organs where cytotoxicity is observed. As a part of the Japanese Center for the... |
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Multiple programmed cell death pathways are involved in N-methyl-N-nitrosourea-induced photoreceptor degeneration.
Graefes Arch. Clin. Exp. Ophthalmol. 253 , 721-31, (2015) To identify programmed cell death (PCD) pathways involved in N-methyl-N-nitrosourea (MNU)-induced photoreceptor (PR) degeneration.Adult C57BL/6 mice received a single MNU i.p. injection (60 mg/kg bodyweight), and were observed over a period of 7 days. Degener... |
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DNA damage response in neonatal and adult stromal cells compared with induced pluripotent stem cells.
Stem Cells Transl. Med. 4 , 576-89, (2015) Comprehensive analyses comparing individual DNA damage response (DDR) of induced pluripotent stem cells (iPSCs) with neonatal stromal cells with respect to their developmental age are limited. The imperative necessity of providing developmental age-matched ce... |
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Breast Cancer Tissue Marked Selectively by Magnetic Nanoparticles in an Experimental Animal Model.
J. Nanosci. Nanotechnol. 15 , 9591-6, (2015) The use of magnetic nanoparticles have been proposed as alternative techniques to assist breast cancer diagnosis and treatment. Peritumoral and intratumoral biodistribution of magnetic nanoparticles have been the main practical approaches, and the evaluation ... |
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Cardiac protective effects of dexrazoxane on animal cardiotoxicity model induced by anthracycline combined with trastuzumab is associated with upregulation of calpain-2.
Medicine (Baltimore.) 94(4) , e445, (2015) Cardiotoxicity is a well-recognized side effect induced by chemotherapeutic drugs such as anthracycline and trastuzumab through different mechanisms. Currently, accumulating evidence supports that dexrazoxane (DZR) can minimize the risk of cardiotoxicity. In ... |
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Intravesical bacillus Calmette-Guérin efficiently reduces p70S6K1 but not 4E-BP1 phosphorylation in nonmuscle invasive bladder cancer.
J. Urol. 193(2) , 682-9, (2015) We characterized the functional consequences of intravesical bacillus Calmette-Guérin on the molecular mechanism of the AKT/mTOR signaling pathway in nonmuscle invasive bladder cancer. To our knowledge this has not been reported previously.At age 7 weeks fema... |
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Base excision DNA repair defect in thioredoxin-1 (Trx1)-deficient cells.
Mutat. Res. 751-752 , 1-7, (2013) Thioredoxin-1 (Trx1) is an antioxidant enzyme with a protective role in the removal of oxidative stress. We investigated the mechanism by which the redox modulator Trx1 affects base excision repair (BER) activity to understand the protective role of Trx1. We ... |
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Arachidonic acid supplementation during gestational, lactational and post-weaning periods prevents retinal degeneration induced in a rodent model.
Br. J. Nutr. 109(8) , 1424-32, (2013) Fatty acids and their derivatives play a role in the response to retinal injury. The effects of dietary arachidonic acid (AA) supplementation on N-methyl-N-nitrosourea (MNU)-induced retinal degeneration was investigated in young Lewis rats during the gestatio... |
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The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine.
PLoS ONE 7(9) , e44817, (2012) O⁶-Methylguanine, one of alkylated DNA bases, is especially mutagenic. Cells containing this lesion are eliminated by induction of apoptosis, associated with the function of mismatch repair (MMR) proteins. A retrovirus-mediated gene-trap mutagenesis was used ... |