Monochlorobimane
Monochlorobimane structure
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Common Name | Monochlorobimane | ||
|---|---|---|---|---|
| CAS Number | 76421-73-3 | Molecular Weight | 226.66000 | |
| Density | 1.4g/cm3 | Boiling Point | 314.9ºC at 760 mmHg | |
| Molecular Formula | C10H11ClN2O2 | Melting Point | 135-136ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 144.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3.
Mol. Cell. Biol. 35 , 3646-56, (2015) Increased production of mitochondrion-derived reactive oxygen species (ROS) is characteristic of a metabolic shift observed during malignant transformation. While the exact sources and roles of ROS in tumorigenesis remain to be defined, it has become clear th... |
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Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA.
Biochim. Biophys. Acta 1840(9) , 2851-61, (2014) Gram-positive bacteria in the phylum Firmicutes synthesize the low molecular weight thiol bacillithiol rather than glutathione or mycothiol. The bacillithiol transferase YfiT from Bacillus subtilis was identified as a new member of the recently discovered Din... |
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All-trans retinoic acid prevents oxidative stress-induced loss of renal tight junction proteins in type-1 diabetic model.
J. Nutr. Biochem. 26 , 441-54, (2015) We previously reported that diabetes decreased the expression of renal tight junction (TJ) proteins claudin-5 in glomerulus, and claudin-2 and occludin in proximal tubule through an oxidative stress dependent way. Now we investigated whether all-trans retinoi... |
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C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress.
Mol. Cell Biochem. 406 , 183-97, (2015) The potential of C-phycocyanin (C-PC) to prevent cisplatin (CP)-induced kidney mitochondrial dysfunction was determined in CD-1 male mice. The CP-induced mitochondrial dysfunction was characterized by ultrastructural abnormalities and by decrease in the follo... |
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Immunotoxicity in ascidians: antifouling compounds alternative to organotins-IV. The case of zinc pyrithione.
Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 169 , 16-24, (2015) New biocides such as the organometallic compound zinc pyrithione (ZnP) have been massively introduced by many countries in formulations of antifouling paints following the ban on tributyltin (TBT). The effects of sublethal concentrations (LC50=82.5 μM, i.e., ... |
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Uptake and cytotoxicity of docetaxel-loaded hyaluronic acid-grafted oily core nanocapsules in MDA-MB 231 cancer cells.
Pharm. Res. 31(9) , 2439-52, (2014) It is hypothesized that docetaxel (Doc)-loaded hyaluronic acid (HA)-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules (NCs) can enhance the drug cytotoxicity and uptake in CD44 expressing breast cancer (BC) cells (MDA-MB 231).NCs were pr... |
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Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney.
Arch. Toxicol. 89 , 2273-89, (2015) Cadmium (Cd(2+)) induces oxidative stress that ultimately defines cell fate and pathology. Mitochondria are the main energy-producing organelles in mammalian cells, but they also have a central role in formation of reactive oxygen species, cell injury, and de... |
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Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.
Neurobiol. Dis. 81 , 76-92, (2015) Gene multiplications or point mutations in alpha (α)-synuclein are associated with familial and sporadic Parkinson's disease (PD). An increase in copper (Cu) levels has been reported in the cerebrospinal fluid and blood of PD patients, while occupational expo... |
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Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin.
Biol. Trace Elem. Res. 167 , 130-45, (2015) Hexavalent chromium [Cr(VI)] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about Cr(VI) toxicity, the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it h... |
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Role of iron, zinc and reduced glutathione in oxidative stress induction by low pH in rat brain synaptosomes.
Springerplus 3 , 560, (2014) Brain ischemia leads to a decrease in pHo. We have shown previously in synaptosomes that the extracellular acidification induces depolarization of mitochondria followed by synthesis of superoxide anions and oxidative stress. Here, we investigated the effects ... |