DiSC3(5)
DiSC3(5) structure
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Common Name | DiSC3(5) | ||
|---|---|---|---|---|
| CAS Number | 53213-94-8 | Molecular Weight | 546.53000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H27IN2S2 | Melting Point | 245ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Negatively Charged Lipids as a Potential Target for New Amphiphilic Aminoglycoside Antibiotics: A BIOPHYSICAL STUDY.
J. Biol. Chem. 291 , 13864-74, (2016) Bacterial membranes are highly organized, containing specific microdomains that facilitate distinct protein and lipid assemblies. Evidence suggests that cardiolipin molecules segregate into such microdomains, probably conferring a negative curvature to the in... |
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A short-chain alkyl derivative of Rhodamine 19 acts as a mild uncoupler of mitochondria and a neuroprotector.
Biochim. Biophys. Acta 1837(10) , 1739-47, (2014) Limited uncoupling of oxidative phosphorylation is known to be beneficial in various laboratory models of diseases. The search for cationic uncouplers is promising as their protonophorous effect is self-limiting because these uncouplers lower membrane potenti... |
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Myricetin inhibits the release of glutamate in rat cerebrocortical nerve terminals.
J. Med. Food 18 , 516-23, (2015) The excessive release of glutamate is a critical element in the neuropathology of acute and chronic brain disorders. The purpose of the present study was to investigate the effect and possible mechanism of myricetin, a naturally occurring flavonoid with a neu... |
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Cyclooxygenase 2 inhibitor celecoxib inhibits glutamate release by attenuating the PGE2/EP2 pathway in rat cerebral cortex endings.
J. Pharmacol. Exp. Ther. 351(1) , 134-45, (2014) The excitotoxicity caused by excessive glutamate is a critical element in the neuropathology of acute and chronic brain disorders. Therefore, inhibition of glutamate release is a potentially valuable therapeutic strategy for treating these diseases. In this s... |
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Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats.
Neurotoxicology 50 , 157-69, (2015) The citrus flavonoid hesperidin exerts neuroprotective effects and could cross the blood-brain barrier. Given the involvement of glutamate neurotoxicity in the pathogenesis of neurodegenerative disorders, this study was conducted to evaluate the potential rol... |
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Glutamine, glutamate, and arginine-based acid resistance in Lactobacillus reuteri.
Food Microbiol. 42 , 172-80, (2014) This study aimed to determine whether glutamine deamidation improves acid resistance of Lactobacillus reuteri, and to assess whether arginine, glutamine, and glutamate-mediated acid resistance are redundant or complementary mechanisms of acid resistance. Thre... |
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Lipopolysaccharide Neutralization by Cationic-Amphiphilic Polymers through Pseudoaggregate Formation.
Biomacromolecules 17 , 862-73, (2016) Synthetic polymers incorporating the cationic charge and hydrophobicity to mimic the function of antimicrobial peptides (AMPs) have been developed. These cationic-amphiphilic polymers bind to bacterial membranes that generally contain negatively charged phosp... |
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Short, multiple-stranded β-hairpin peptides have antimicrobial potency with high selectivity and salt resistance.
Acta Biomater. 30 , 78-93, (2015) The β-hairpin structure has been proposed to exhibit potent antimicrobial properties with low cytotoxicity, thus, multiple β-hairpin structures have been proved to be highly stable in structures containing tightly packed hydrophobic cores. The aim of this stu... |
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Transmembrane potential measurement with carbocyanine dye diS-C3-(5): fast fluorescence decay studies.
J. Photochem. Photobiol. B, Biol. 4 , 321, (1990) The mechanism of carbocyanine dye diS-C3-(5) fluorescence intensity variations with transmembrane potential changes has been studied using time-resolved fluorescence spectroscopy. Clear evidence is given of the transmembrane-potential-dependent partition of t... |
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The antifungal activity and membrane-disruptive action of dioscin extracted from Dioscorea nipponica.
Biochim. Biophys. Acta 1828 , 1153-1158, (2012) Dioscin is a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica. We investigated the antifungal effect of dioscin against different fungal strains and its antifungal mechanism(s) in Candida albicans cells. Using the propidiu... |