Fadrozole hydrochloride
Fadrozole hydrochloride structure
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Common Name | Fadrozole hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 102676-31-3 | Molecular Weight | 259.73400 | |
| Density | N/A | Boiling Point | 481.7ºC at 760mmHg | |
| Molecular Formula | C14H14ClN3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 245.1ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Transdifferentiation of differentiated ovary into functional testis by long-term treatment of aromatase inhibitor in Nile tilapia.
Endocrinology 155(4) , 1476-88, (2014) Females with differentiated ovary of a gonochoristic fish, Nile tilapia, were masculinized by long-term treatment with an aromatase inhibitor (Fadrozole) in the present study. The reversed gonads developed into functional testes with fertile sperm. The longer... |
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Masculinisation of the zebra finch song system: roles of oestradiol and the Z-chromosome gene tubulin-specific chaperone protein A.
J. Neuroendocrinol. 27(5) , 324-34, (2015) Robust sex differences in brain and behaviour exist in zebra finches. Only males sing, and forebrain song control regions are more developed in males. The factors driving these differences are not clear, although numerous experiments have shown that oestradio... |
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In vivo response of melatonin, gonadal activity and biochemical changes during CYP19 inhibited sex reversal in common carp Cyprinus carpio (L).
Anim. Reprod. Sci. 136(4) , 317-25, (2013) CYP19 aromatase is the key enzyme in vertebrate steroidogenesis, catalyzing the conversion of C19 androgens to 17β-estradiol (E(2)). The objective of the present study was to assess the effect of the CYP19 inhibitors (AIs) fadrozole and anastrozole on gonadal... |
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Role of aromatase in sex-specific cerebrovascular endothelial function in mice.
Am. J. Physiol. Heart Circ. Physiol. 306(7) , H929-37, (2014) Stroke risk and outcome are strongly modified by estrogen. In addition to ovaries, estrogen is produced locally in peripheral tissue by the enzyme aromatase, and extragonadal synthesis becomes the major source of estrogen after menopause. Aromatase gene delet... |
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Sex steroids stimulate leptin gene expression in Atlantic salmon parr hepatocytes in vitro.
Gen. Comp. Endocrinol. 221 , 156-64, (2015) In mammals, leptin plays an important role in puberty and reproduction and leptin is regulated by sex steroids. Elevated leptin levels have been associated with sexual maturation in some teleosts such as Atlantic salmon. In the present study, primary cultures... |
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Structural insights into aldosterone synthase substrate specificity and targeted inhibition.
Mol. Endocrinol. 27(2) , 315-24, (2013) Aldosterone is a major mineralocorticoid hormone that plays a key role in the regulation of electrolyte balance and blood pressure. Excess aldosterone levels can arise from dysregulation of the renin-angiotensin-aldosterone system and are implicated in the pa... |
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Rapid and widespread effects of 17β-estradiol on intracellular signaling in the male songbird brain: a seasonal comparison.
Endocrinology 153(3) , 1364-76, (2012) Across vertebrate species, 17β-estradiol (E(2)) acts on the brain via both genomic and nongenomic mechanisms to influence neuronal physiology and behavior. Nongenomic E(2) signaling is typically initiated by membrane-associated estrogen receptors that modulat... |
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Neovascularization is attenuated with aldosterone synthase inhibition in rats with retinopathy.
Hypertension 59(3) , 607-13, (2012) Neovascularization is a hallmark feature of retinopathy of prematurity and diabetic retinopathy. Type 1 angiotensin receptor blockade reduces neovascularization in experimental retinopathy of prematurity, known as oxygen-induced retinopathy (OIR). We investig... |
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Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).
J. Med. Chem. 53 , 1712-25, (2010) Reducing aldosterone action is beneficial in various major diseases such as heart failure. Currently, this is achieved with mineralocorticoid receptor antagonists, however, aldosterone synthase (CYP11B2) inhibitors may offer a promising alternative. In this s... |
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Central neuronal activation and pressor responses induced by circulating ANG II: role of the brain aldosterone-"ouabain" pathway.
Am. J. Physiol. Heart Circ. Physiol. 299(2) , H422-30, (2010) An increase in plasma ANG II causes neuronal activation in hypothalamic nuclei and a slow pressor response, presumably by increasing sympathetic drive. We evaluated whether the activation of a neuromodulatory pathway, involving aldosterone and "ouabain," is i... |