Fadrozole hydrochloride
Modify Date: 2024-01-04 20:24:57
Fadrozole hydrochloride structure
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Common Name | Fadrozole hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 102676-31-3 | Molecular Weight | 259.73400 | |
| Density | N/A | Boiling Point | 481.7ºC at 760mmHg | |
| Molecular Formula | C14H14ClN3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 245.1ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
Use of Fadrozole hydrochlorideFadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. |
| Name | Fadrozole |
|---|---|
| Synonym | More Synonyms |
| Description | Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 6.4 nM (aromatase)[1] |
| In Vitro | Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. In hamster ovarian slices, Fadrozole hydrochloride inhibits the production of estrogen with an IC50 of 0.03 μM. The production of progesterone is inhibited with an IC50 of 120 μM. Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of Fadrozole hydrochloride[1]. |
| In Vivo | Fadrozole hydrochloride is able to inhibit the aromatase-mediated androstenedione-induced uterine hypertrophy in immature female rats with an ED50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED50 of 30 mg/kg when given orally[1]. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars distalis adenomas in female rats, and reduces the incidence of spontaneous hepatocellular tumours in male and female rats[2]. Administration of Fadrozole hydrochloride in male and female mice suppresses the production of 17b-estradiol, accompanied with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole hydrochloride treatment returns these levels to baseline values[3]. |
| Animal Admin | Rats: Rats are treated with daily dosing with Fadrozole hydrochloride in purified water by gavage for 2 years. There are 60 rats in each of four groups given 0, 0.05, 0.25 or 1.25 mg/kg daily. Control rats receive only water. Clinical signs are recorded weekly and the animals are examined for palpable masses every 4 weeks for the first 9 months, then every 2 weeks for the remainder of the study[2]. Mice: Fadrozole hydrochloride is administered in the form of sub-dermal long-term release pellets (20 mg/wt kg, in three-week-release pellets), starting 1 week prior to the infection, using a 10-gauge needle. Three pellets are administrated during the study. Placebo pellets are administered to another group of infected mice, in the same fashion as the inhibitor. After 1 week, mice are infected and killed 8 weeks later[3]. |
| References |
| Boiling Point | 481.7ºC at 760mmHg |
|---|---|
| Molecular Formula | C14H14ClN3 |
| Molecular Weight | 259.73400 |
| Flash Point | 245.1ºC |
| Exact Mass | 259.08800 |
| PSA | 41.61000 |
| LogP | 3.48248 |
| Vapour Pressure | 1.95E-09mmHg at 25°C |
| Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H361 |
| Precautionary Statements | P281-P301 + P310 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | R22;R63 |
| Safety Phrases | S36/S37 |
| RIDADR | UN 2811 6.1 / PGIII |
| RTECS | DI4952500 |
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Transdifferentiation of differentiated ovary into functional testis by long-term treatment of aromatase inhibitor in Nile tilapia.
Endocrinology 155(4) , 1476-88, (2014) Females with differentiated ovary of a gonochoristic fish, Nile tilapia, were masculinized by long-term treatment with an aromatase inhibitor (Fadrozole) in the present study. The reversed gonads deve... |
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Masculinisation of the zebra finch song system: roles of oestradiol and the Z-chromosome gene tubulin-specific chaperone protein A.
J. Neuroendocrinol. 27(5) , 324-34, (2015) Robust sex differences in brain and behaviour exist in zebra finches. Only males sing, and forebrain song control regions are more developed in males. The factors driving these differences are not cle... |
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In vivo response of melatonin, gonadal activity and biochemical changes during CYP19 inhibited sex reversal in common carp Cyprinus carpio (L).
Anim. Reprod. Sci. 136(4) , 317-25, (2013) CYP19 aromatase is the key enzyme in vertebrate steroidogenesis, catalyzing the conversion of C19 androgens to 17β-estradiol (E(2)). The objective of the present study was to assess the effect of the ... |
| FADROZOLE HCL |
| +-5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine hydrochloride |
| Fadrazole |
| fadrozole hydrochloride |
| 4-(5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL)BENZONITRILE HYDROCHLORIDE |
| 4-(5,6,7,8-tetrahydro-imidazo-[1,5a]-pyridin-5-yl)benzonitrile monohydrochloride |
| MFCD00866239 |
| 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonitrile |
| 5-(4-cyanophenyl)-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Fadrozole hydrochloride
- Price: ￥998.0/10mg ￥4008.0/50mg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Fadrozole (hydrochloride)
- Price: $450.0/100mg $900.0/250mg $1800.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: FADROZOLE HYDROCHLORIDE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
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