4-DAMP
4-DAMP structure
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Common Name | 4-DAMP | ||
|---|---|---|---|---|
| CAS Number | 1952-15-4 | Molecular Weight | 451.34 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H26INO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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A Distinct Class of Slow (∼0.2-2 Hz) Intrinsically Bursting Layer 5 Pyramidal Neurons Determines UP/DOWN State Dynamics in the Neocortex.
J. Neurosci. 35(14) , 5442-58, (2015) During sleep and anesthesia, neocortical neurons exhibit rhythmic UP/DOWN membrane potential states. Although UP states are maintained by synaptic activity, the mechanisms that underlie the initiation and robust rhythmicity of UP states are unknown. Using a p... |
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Activation of muscarinic M3 receptors inhibits large-conductance voltage- and Ca2+-activated K+ channels in rat urinary bladder smooth muscle cells.
Am. J. Physiol. Cell Physiol. 305(2) , C207-14, (2013) Large conductance voltage- and Ca(2+)-activated K(+) (BK) channels are key regulators of detrusor smooth muscle (DSM) contraction and relaxation during urine voiding and storage. Here, we explored whether BK channels are regulated by muscarinic receptors (M-R... |
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Evidence for respiratory neuromodulator interdependence after cholinergic disruption in the ventral respiratory column.
Respir. Physiol. Neurobiol. 205 , 7-15, (2014) Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50 mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breathing frequency and serotonin (5-HT), substance P (SP), glyc... |
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In vitro effects of the organophosphorus pesticide malathion on the reactivity of rat aorta.
Pharmacology 94(3-4) , 157-62, (2014) There is a remarkable paucity of studies analyzing the role of the endothelium-derived relaxing factors on the vascular effects of organophosphates. This study was carried out to evaluate the vascular effects of malathion and the role of nitric oxide (NO) and... |
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The role of muscarinic receptor subtypes on carbachol-induced contraction of normal human detrusor and overactive detrusor associated with benign prostatic hyperplasia.
J. Pharmacol. Sci. 128 , 65-70, (2015) The aim of this study was to compare the effect of antimuscarinic antagonists on carbachol-induced contraction of normal human bladder and detrusor overactivity associated with benign prostatic hyperplasia (DO/BPH). Samples of human bladder muscle were obtain... |
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The actions of neurotensin in rat bladder detrusor contractility.
Sci. Rep. 5 , 11192, (2015) This study assessed the expression, distribution and function of neurotensin (NTs) and two main neurotensin receptors (NTSR), NTSR1 and NTSR2 in normal rat urinary bladders. NTs is primarily located in the suburothelium and the interstitium of smooth muscle b... |
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Muscarinic M1 receptors regulate propofol modulation of GABAergic transmission in rat ventrolateral preoptic neurons.
J. Mol. Neurosci. 55(4) , 830-5, (2015) GABAergic neurons within the ventrolateral preoptic area (VLPO) play an important role in sleep-wakefulness regulation. Propofol, a widely used systemic anesthetic, has lately been reported to excite noradrenaline (NA)-inhibited type of VLPO neurons. Present ... |
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Regulation of the perilymphatic-endolymphatic water shunt in the cochlea by membrane translocation of aquaporin-5.
Pflugers Arch. 467 , 2571-88, (2015) Volume homeostasis of the cochlear endolymph depends on radial and longitudinal endolymph movements (LEMs). LEMs measured in vivo have been exclusively recognized under physiologically challenging conditions, such as experimentally induced alterations of peri... |
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Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon.
Mucosal Immunol. 8(1) , 198-210, (2014) The delivery of luminal substances across the intestinal epithelium to the immune system is a critical event in immune surveillance, resulting in tolerance to dietary antigens and immunity to pathogens. How this process is regulated is largely unknown. Recent... |
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Acupuncture at heterotopic acupoints facilitates distal colonic motility via activating M3 receptors and somatic afferent C-fibers in normal, constipated, or diarrhoeic rats.
Neurogastroenterol. Motil. 27 , 1817-30, (2015) Previous studies have demonstrated the efficacy of somatic stimulation for patients with gastrointestinal motility disorders. However, little effort has been made to investigate the effects of acupuncture on colonic motility, particularly in pathological cond... |