4-DAMP

Modify Date: 2024-01-11 17:55:19

4-DAMP Structure
4-DAMP structure
Common Name 4-DAMP
CAS Number 1952-15-4 Molecular Weight 451.34
Density N/A Boiling Point N/A
Molecular Formula C21H26INO2 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of 4-DAMP


4-DAMP is a potent antagonist of M3 receptor and also has a high affinity for the closely-related M5 receptor[1].

 Names

Name (1,1-dimethylpiperidin-1-ium-4-yl) 2,2-diphenylacetate,iodide
Synonym More Synonyms

 4-DAMP Biological Activity

Description 4-DAMP is a potent antagonist of M3 receptor and also has a high affinity for the closely-related M5 receptor[1].
Related Catalog
References

[1]. Watson N, et al. Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO-K1 cells. Br J Pharmacol. 1999 May;127(2):590-6.

 Chemical & Physical Properties

Molecular Formula C21H26INO2
Molecular Weight 451.34
Exact Mass 451.100800
PSA 26.30000
LogP 0.56330

 Safety Information

RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933399090

 Synthetic Route

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4-DAMP Structure

4-DAMP

CAS#:1952-15-4

Literature: Journal of Organic Chemistry, , vol. 20, p. 774,776

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4-DAMP Structure

4-DAMP

CAS#:1952-15-4

Literature: Journal of Organic Chemistry, , vol. 20, p. 774,776

~%

4-DAMP Structure

4-DAMP

CAS#:1952-15-4

Literature: Journal of Organic Chemistry, , vol. 20, p. 774,776

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles61

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During sleep and anesthesia, neocortical neurons exhibit rhythmic UP/DOWN membrane potential states. Although UP states are maintained by synaptic activity, the mechanisms that underlie the initiation...

Activation of muscarinic M3 receptors inhibits large-conductance voltage- and Ca2+-activated K+ channels in rat urinary bladder smooth muscle cells.

Am. J. Physiol. Cell Physiol. 305(2) , C207-14, (2013)

Large conductance voltage- and Ca(2+)-activated K(+) (BK) channels are key regulators of detrusor smooth muscle (DSM) contraction and relaxation during urine voiding and storage. Here, we explored whe...

Evidence for respiratory neuromodulator interdependence after cholinergic disruption in the ventral respiratory column.

Respir. Physiol. Neurobiol. 205 , 7-15, (2014)

Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50 mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breat...

 Synonyms

4-diphenylacetoxy-1,1-dimethyl-piperidinium,iodide
4-(2,2-Diphenylacetoxy)-1,1-dimethylpiperidinium iodide
4-Damp methiodide
4-DAMP methyliodide
4-diphenylacetoxy-N-methylpiperidinemethiodide
4-DAMP
4-[(diphenylacetyl)oxy]-1,1-dimethylpiperidinium iodide
diphenylacetoxy-N-methylpiperidine methiodide
MFCD00078564
4-Diphenylacetoxy-N-methylpiperidine methiodide
4-DAMP iodide
4-Diphenylacetoxy-1,1-dimethyl-piperidinium,Jodid
Piperidinium, 4-[(2,2-diphenylacetyl)oxy]-1,1-dimethyl-, iodide (1:1)