4-DAMP

Names

[ CAS No. ]:
1952-15-4

[ Name ]:
4-DAMP

[Synonym ]:
4-diphenylacetoxy-1,1-dimethyl-piperidinium,iodide
4-(2,2-Diphenylacetoxy)-1,1-dimethylpiperidinium iodide
4-Damp methiodide
4-DAMP methyliodide
4-diphenylacetoxy-N-methylpiperidinemethiodide
4-DAMP
4-[(diphenylacetyl)oxy]-1,1-dimethylpiperidinium iodide
diphenylacetoxy-N-methylpiperidine methiodide
MFCD00078564
4-Diphenylacetoxy-N-methylpiperidine methiodide
4-DAMP iodide
4-Diphenylacetoxy-1,1-dimethyl-piperidinium,Jodid
Piperidinium, 4-[(2,2-diphenylacetyl)oxy]-1,1-dimethyl-, iodide (1:1)

Biological Activity

[Description]:

4-DAMP is a potent antagonist of M3 receptor and also has a high affinity for the closely-related M5 receptor[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Inflammation/Immunology

[References]

[1]. Watson N, et al. Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO-K1 cells. Br J Pharmacol. 1999 May;127(2):590-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₆INO₂

[ Molecular Weight ]:
451.34

[ Exact Mass ]:
451.100800

[ PSA ]:
26.30000

[ LogP ]:
0.56330

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A Distinct Class of Slow (∼0.2-2 Hz) Intrinsically Bursting Layer 5 Pyramidal Neurons Determines UP/DOWN State Dynamics in the Neocortex.

J. Neurosci. 35(14) , 5442-58, (2015)

During sleep and anesthesia, neocortical neurons exhibit rhythmic UP/DOWN membrane potential states. Although UP states are maintained by synaptic activity, the mechanisms that underlie the initiation...

Activation of muscarinic M3 receptors inhibits large-conductance voltage- and Ca2+-activated K+ channels in rat urinary bladder smooth muscle cells.

Am. J. Physiol. Cell Physiol. 305(2) , C207-14, (2013)

Large conductance voltage- and Ca(2+)-activated K(+) (BK) channels are key regulators of detrusor smooth muscle (DSM) contraction and relaxation during urine voiding and storage. Here, we explored whe...

Evidence for respiratory neuromodulator interdependence after cholinergic disruption in the ventral respiratory column.

Respir. Physiol. Neurobiol. 205 , 7-15, (2014)

Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50 mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breat...