Sphingosine-1-phosphate
Sphingosine-1-phosphate structure
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Common Name | Sphingosine-1-phosphate | ||
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| CAS Number | 26993-30-6 | Molecular Weight | 379.472 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 548.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H38NO5P | Melting Point | 190ºC | |
| MSDS | Chinese USA | Flash Point | 285.7±32.9 °C | |
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The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production.
Biochem. Biophys. Res. Commun. 463 , 545-50, (2015) In the current study, we investigated the potential activity of AR-42, a novel histone deacetylase (HDAC) inhibitor, against colon cancer cells. Our in vitro results showed that AR-42 induced ceramide production, exerted potent anti-proliferative and pro-apop... |
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Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen.
Biochim. Biophys. Acta 1841(6) , 836-46, (2014) Both sphingosine 1-phosphate (S1P) and estrogen have been documented to play endothelial protective roles. However, it remains unclear whether estrogen could regulate the anabolism of the bioactive molecule S1P and the underlying mechanisms. In this study, 10... |
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The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development.
Development 141(23) , 4513-25, (2014) Low density lipoprotein receptor-related protein 1 (LRP1) is indispensable for embryonic development. Comparing different genetically engineered mouse models, we found that expression of Lrp1 is essential in the embryo proper. Loss of LRP1 leads to lethal vas... |
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Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation.
J. Cell Physiol. 230(3) , 702-15, (2015) Sphingosine-1-phosphate (S1P) has been shown to regulate cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2 ) expression and IL-6 secretion in various respiratory diseases. However, the mechanisms underlying S1P-induced COX-2 expression and PGE2 production in hu... |
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Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis.
Dev. Dyn. 244 , 948-54, (2015) The sphingosine 1-phosphate (S1P) signaling pathway regulates zebrafish cardiogenesis, and provides a paradigm for how signaling gradients coordinate collective cell migration across tissue layers. It is known that the S1P transporter (Spns2) functions in ext... |
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An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production.
Mol. Cell. Biol. 34(24) , 4368-78, (2014) Antimicrobial peptides (AMP) are ubiquitous innate immune elements in epithelial tissues. We recently discovered that a signaling lipid, the ceramide metabolite sphingosine-1-phosphate (S1P), regulates production of a major AMP, cathelicidin antimicrobial pep... |
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Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer.
Mol. Immunol. 63(1) , 104-12, (2015) Mast cells (MC) are found in all vascularized tissues at homeostasis and, until recently, were viewed only as effector cells of allergic reactions via degranulation, the canonical process through which MC release mediators, including histamine and pre-formed ... |
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[Sphingolipids, possible biomarkers for atherosclerotic disorders].
Rinsho Byori. 61(9) , 795-802, (2013) Sphingolipids have been recently elucidated to be not only mere components of the plasma membrane but also bioactive mediators which can induce various biological responses. Among these lipids, sphingomyelin(SM) and sphingosine 1-phosphate (Sph-1-P) are propo... |
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[Lymphocytes mobilization into blood regulated by Spns2, a sphingosine 1-phosphate transporter, expressed on endothelial cells].
Seikagaku. 85(4) , 269-72, (2013)
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Pharmacology of the sphingosine-1-phosphate signalling system.
Handbook of Experimental Pharmacology (215) , 239-53, (2013) The recent success of FTY720 (Fingolimod, Gilenya(®)), which has been approved for the treatment of relapsing-remitting multiple sclerosis and is the first-in-class sphingosine-1-phosphate (S1P) receptor modulating drug, has boosted the interest in further dr... |