Sphingosine-1-phosphate
Modify Date: 2024-01-08 13:15:24
Sphingosine-1-phosphate structure
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Common Name | Sphingosine-1-phosphate | ||
|---|---|---|---|---|
| CAS Number | 26993-30-6 | Molecular Weight | 379.472 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 548.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H38NO5P | Melting Point | 190ºC | |
| MSDS | Chinese USA | Flash Point | 285.7±32.9 °C | |
Use of Sphingosine-1-phosphateSphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2]. |
| Name | sphingosine 1-phosphate |
|---|---|
| Synonym | More Synonyms |
| Description | Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | S1P (1 μM) induces a significant Ca2+ releases in HEK293 cells under serum starvation conditions (1% FCS)[1]. In a functional Ca2+ assay, Suramin (HY-B0879) alone does not exert any effect on intracellular Ca2+ release via gpr3, gpr6 or gpr12. In contrast, S1P (1 μM) induces Ca2+ release of gpr3, gpr6 and gpr12 in the presence of Suramin (HY-B0879) various concentrations in transfected HEK293 cells[2]. In a functional Ca2+ assay,S1P (3-3000 nM) in the presence Suramin (300 μM), exhibits nanomolar EC50 values for gpr3 (EC50=29 nM), gpr6 (EC50=15 nM) and gpr12 (EC50=24 nM), rat gpr3 (EC50=68 nM),respectively in HEK293 cells[2]. S1P increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively)[3]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 548.8±60.0 °C at 760 mmHg |
| Melting Point | 190ºC |
| Molecular Formula | C18H38NO5P |
| Molecular Weight | 379.472 |
| Flash Point | 285.7±32.9 °C |
| Exact Mass | 379.248749 |
| PSA | 122.82000 |
| LogP | 5.46 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.501 |
| Storage condition | −20°C |
| Stability | Moisture, Temperature Sensitive; Hygroscopic |
| Water Solubility | methanol: THF: water (6:3:1): >0.5 mg/mL |
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CAS#:1093733-24-4| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production.
Biochem. Biophys. Res. Commun. 463 , 545-50, (2015) In the current study, we investigated the potential activity of AR-42, a novel histone deacetylase (HDAC) inhibitor, against colon cancer cells. Our in vitro results showed that AR-42 induced ceramide... |
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Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen.
Biochim. Biophys. Acta 1841(6) , 836-46, (2014) Both sphingosine 1-phosphate (S1P) and estrogen have been documented to play endothelial protective roles. However, it remains unclear whether estrogen could regulate the anabolism of the bioactive mo... |
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The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development.
Development 141(23) , 4513-25, (2014) Low density lipoprotein receptor-related protein 1 (LRP1) is indispensable for embryonic development. Comparing different genetically engineered mouse models, we found that expression of Lrp1 is essen... |
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| (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate D-erythro-Sphingosine 1-phosphate |
| [(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate |
| Sphing-4-enine 1-phosphate |
| 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (4E)- |
| C18-Sphingosine 1-phosphate |
| D-erythro-sphingosine-1-phosphate |
| Sphingosine 1-phosphate |
| Dihydrogène phosphate de (4E)-2-amino-3-hydroxy-4-octadécèn-1-yle |
| MFCD00274457 |
| S1P |
| Sphingosine 1-phosphic acid |
| (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate,D-erythro-Sphingosine 1-phosphate |
| D-erythro-Sphingosine 1-phosphate |
| Somatostatin 1-28 |
| (4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate |
| (4E)-2-Amino-3-hydroxy-4-octadecen-1-yl dihydrogen phosphate |
- Shanghai Jizhi Biochemical Technology Co., Ltd
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- Product Name: Sphingosine-1-phosphate
- Price: ￥988.0/1mg ￥3508.0/5mg
- Purity: 98.0%
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- DC Chemicals Limited
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: D-erythro-sphingosine-1-phosphate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
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