O-Ethyl O-(4-nitrophenyl) phenylphosphonothioate
O-Ethyl O-(4-nitrophenyl) phenylphosphonothioate structure
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Common Name | O-Ethyl O-(4-nitrophenyl) phenylphosphonothioate | ||
|---|---|---|---|---|
| CAS Number | 2104-64-5 | Molecular Weight | 323.304 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 434.5±47.0 °C at 760 mmHg | |
| Molecular Formula | C14H14NO4PS | Melting Point | 36ºC | |
| MSDS | Chinese USA | Flash Point | 216.6±29.3 °C | |
| Symbol |
GHS06, GHS09 |
Signal Word | Danger | |
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A multiresidue method for the analysis of pesticide residues in polished rice (Oryza sativa L.) using accelerated solvent extraction and gas chromatography and confirmation by mass spectrometry.
Biomed. Chromatogr. 21(6) , 602-9, (2007) An analytical procedure using accelerated solvent extraction and gas chromatography with an electron capture detector has been optimized to simultaneously determine the residue of two insecticides (diazinon and EPN) and one fungicide (isoprothiolane) in polis... |
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Mechanisms of joint neurotoxicity of n-hexane, methyl isobutyl ketone and O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens.
J. Pharmacol. Exp. Ther. 257(1) , 282-9, (1991) The joint neurotoxic action of simultaneous exposure to vapors of n-hexane and methyl iso-butyl ketone (MiBK) and dermally applied O-ethyl O-nitrophenyl phenylphosphonothioate (EPN) was studied in groups of five adult hens. Four groups of hens were concurrent... |
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Lack of promoting activity of four pesticides on induction of preneoplastic liver cell foci in rats.
Teratog. Carcinog. Mutagen. 15(5) , 251-7, (1995) Four pesticides were examined for hepatopromoting activity using a medium-term bioassay based upon induction of glutathione S-transferase placental form (GST-P) positive foci in the rat liver. Male F344 rats were initially injected with diethylnitrosamine (DE... |
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Protective effect of a high protein diet against the toxicity of some organophosphorus compounds in albino rats.
Jpn. J. Pharmacol. 57(2) , 147-52, (1991) The present investigation deals with determining the efficacy of a high protein diet (HPD) in combating toxicity in albino rats of some organophosphorus compounds (OPCs) that follow dissimilar metabolic patterns in a living system. As assessed by an increase ... |
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Toxicological significance in the cleavage of esterase-beta-glucuronidase complex in liver microsomes by organophosphorus compounds.
Chem. Biol. Interact. 119-120 , 471-8, (1999) Egasyn is an accessory protein of beta-glucuronidase (beta-G) in the liver microsomes. Liver microsomal beta-G is stabilized within the luminal site of the microsomal vesicles by complexation with egasyn which is one of the carboxylesterase isozymes. We inves... |
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Enhancement of the binding of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon) to microsomal carboxylesterase by NAD in vitro.
Jpn. J. Pharmacol. 37(1) , 39-44, (1985) Inhibition of rat liver microsomal carboxylesterase (CEase) by O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) and binding of EPN oxygen analog to microsomal CEase were enhanced by addition of NAD or NADP. This was more prominent in addition of NAD than ... |
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Mutagenesis of organophosphorus hydrolase to enhance hydrolysis of the nerve agent VX.
Biochem. Biophys. Res. Commun. 279(2) , 516-9, (2000) Organophosphorus hydrolase (OPH) is capable of hydrolyzing a wide variety of organophosphorus pesticides and chemical warfare agents. However, the hydrolytic activity of OPH against the warfare agent VX is less than 0.1% relative to its activity against parat... |
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NAD-coupled enzymatic oxidation of O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) to its oxygen analog with liver microsomes of rats.
Jpn. J. Pharmacol. 37(3) , 245-52, (1985) O-Ethyl O-p-nitrophenyl phenylphosphonothioate (EPN)-induced inhibition of rat liver microsomal carboxylesterase (CEase) and formation of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon), an oxygen analog of EPN, were enhanced remarkably by addition of NAD... |
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Biosensor for direct determination of fenitrothion and EPN using recombinant Pseudomonas putida JS444 with surface-expressed organophosphorous hydrolase. 2. Modified carbon paste electrode.
Appl. Biochem. Biotechnol. 136(3) , 243-50, (2007) A whole cell-based amperometric biosensor for highly selective, sensitive, rapid, and cost-effective determination of the organophosphate pesticides fenitrothion and ethyl p-nitrophenol thio-benzene phosphonate (EPN) is discussed. The biosensor comprised gene... |
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Teratogenic evaluation of the pesticides baygon, carbofuran, dimethoate and EPN.
J. Environ. Sci. Health B 20(4) , 373-406, (1985) Baygon was administered IG once daily to CD rats (5 to 50 mg/kg), on the 7th-19th day of gestation or to CD-1 mice (5 to 60 mg/kg) on days 6-16 of gestation. Baygon, at dose levels which were not maternally lethal, did not produce fetotoxicity, fetal lethalit... |