Japanese Journal of Pharmacology 1991-10-01

Protective effect of a high protein diet against the toxicity of some organophosphorus compounds in albino rats.

A K Chatterjee, U Kaveeshwar

Index: Jpn. J. Pharmacol. 57(2) , 147-52, (1991)

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Abstract

The present investigation deals with determining the efficacy of a high protein diet (HPD) in combating toxicity in albino rats of some organophosphorus compounds (OPCs) that follow dissimilar metabolic patterns in a living system. As assessed by an increase or decrease in the levels of some biochemical and nutritional parameters, the high protein diet containing 59% protein seems to have a beneficial effect in alleviating toxicity of low but prolonged doses of OPCs over the standard diet (SD) containing 19% protein. OPCs undergoing direct detoxication in a living system like diisopropyl phosphoro-fluoridate (DFP) appear to be more susceptible to HPD than those undergoing biotoxication like EPN (O-ethyl O-p-nitrophenyl phenyl-phosphonothioate) and malathion (S-(1,2-dicarbethoxyethyl) O,O-dimethyldithiophosphate).