Hexylene glycol
Hexylene glycol structure
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Common Name | Hexylene glycol | ||
|---|---|---|---|---|
| CAS Number | 107-41-5 | Molecular Weight | 118.174 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 197.5±0.0 °C at 760 mmHg | |
| Molecular Formula | C6H14O2 | Melting Point | −40 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 93.9±0.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Self-immolative polycations as gene delivery vectors and prodrugs targeting polyamine metabolism in cancer.
Mol. Pharm. 12(2) , 332-41, (2015) Polycations are explored as carriers to deliver therapeutic nucleic acids. Polycations are conventionally pharmacological inert with the sole function of delivering therapeutic cargo. This study reports synthesis of a self-immolative polycation (DSS-BEN) base... |
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Flavonoid-based pH-responsive hydrogels as carrier of unstable drugs in oxidative conditions.
Pharm. Dev. Technol. 20(3) , 288-96, (2015) In this study, pH-responsive hydrogels, synthesized by the coupling reaction of polyacrylic acid and catechin, are proposed as carriers of oxidable drugs toward the GI tract. The presence of polyphenolic moieties in the network gives the polymers properties s... |
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The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death.
Cell Death Dis. 6 , e1616, (2015) The selenoprotein thioredoxin reductase 1 (TrxR1) has several key roles in cellular redox systems and reductive pathways. Here we discovered that an evolutionarily conserved and surface-exposed tryptophan residue of the enzyme (Trp114) is excessively reactive... |
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Refolding of SDS-denatured proteins using amphipathic cosolvents and osmolytes.
Curr. Protoc. Protein Sci. Chapter 28 , Unit28.5, (2013) Currently, the investigation of protein refolding processes involves several time-consuming stages that require large amounts of protein and costly chemicals. Consequently, there is great interest in developing new approaches to the study of protein renaturat... |
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The structures of transcription factor CGL2947 from Corynebacterium glutamicum in two crystal forms: a novel homodimer assembling and the implication for effector-binding mode.
Protein Sci. 16(9) , 1878-86, (2007) Among the transcription factors, the helix-turn-helix (HTH) GntR family comprised of FadR, HutC, MocR, YtrA, AraR, and PlmA subfamilies regulates the most varied biological processes. Generally, proteins belonging to this family contain an N-terminal DNA-bind... |
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Atomic force microscopy of native human metaphase chromosomes in a liquid.
Arch. Histol. Cytol. 69(1) , 73-8, (2006) The present study introduces a method for obtaining three-dimensional images of native (i.e., unfixed) chromosomes by atomic force microscopy (AFM) in a liquid. Human metaphase chromosomes were isolated from a human lymphoblast-like cell line, K562, by the he... |
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Contact urticaria with systemic symptoms due to hexylene glycol in a topical corticosteroid: case report and review of hypersensitivity to glycols.
Dermatology 220(3) , 238-42, (2010) We report a case of severe contact urticaria with systemic involvement resembling an anaphylactic reaction, following the application of a topical corticosteroid. This was caused by hexylene glycol, an excipient in the formulation. Glycols are widely used in ... |
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Protecting role of cosolvents in protein denaturation by SDS: a structural study.
BMC Struct. Biol. 8 , 29, (2008) Recently, we reported a unique approach to preserve the activity of some proteins in the presence of the denaturing agent, Sodium Dodecyl Sulfate (SDS). This was made possible by addition of the amphipathic solvent 2,4-Methyl-2-PentaneDiol (MPD), used as prot... |
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2-Methyl-2,4-pentanediol induces spontaneous assembly of staphylococcal α-hemolysin into heptameric pore structure.
Protein Sci. 20(2) , 448-56, (2011) Staphylococcal α-hemolysin is expressed as a water-soluble monomeric protein and assembles on membranes to form a heptameric pore structure. The heptameric pore structure of α-hemolysin can be prepared from monomer in vitro only in the presence of deoxycholat... |
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Aqueous self-assembly of phytantriol in ternary systems: effect of monoolein, distearoylphosphatidylglycerol and three water-miscible solvents.
J. Colloid. Interface Sci. 315(2) , 701-13, (2007) The aqueous phase behavior of phytantriol (PT) in mixtures of monoolein (MO), distearoylphosphatidylglycerol (DSPG), propylene glycol (PG), polyethylene glycol 400 (PEG 400) and 2-methyl-2,4-pentanediol (MPD) was investigated by visual inspection, polarized l... |