Farnesyl pyrophosphate
Farnesyl pyrophosphate structure
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Common Name | Farnesyl pyrophosphate | ||
|---|---|---|---|---|
| CAS Number | 13058-04-3 | Molecular Weight | 433.418 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H37N3O7P2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 16 °C - closed cup (lit.) | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation--impact of Ras-/Rho-prenylation.
Pharmacol. Res. 91 , 69-77, (2015) Alterations in small GTPase mediated signal transduction pathways have emerged as a central step in the molecular pathogenesis of glioblastoma (GBM), the most common malignant brain tumor in adults. Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate ... |
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A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast.
PLoS ONE 7(11) , e49004, (2012) Currently, statins are the only drugs acting on the mammalian isoprenoid pathway. The mammalian genes in this pathway are not easily amenable to genetic manipulation. Thus, it is difficult to study the effects of the inhibition of various enzymes on the inter... |
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In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.
Br. J. Cancer 111(8) , 1562-71, (2014) The increasing usage of statins (the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) has revealed a number of unexpected beneficial effects, including a reduction in cancer risk.We investigated the direct anticancer effects of different statins ap... |
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Transcriptome profiling provides new insights into the formation of floral scent in Hedychium coronarium.
BMC Genomics 16 , 470, (2015) Hedychium coronarium is a popular ornamental plant in tropical and subtropical regions because its flowers not only possess intense and inviting fragrance but also enjoy elegant shape. The fragrance results from volatile terpenes and benzenoids presented in t... |
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Inhibition of the mevalonate pathway ameliorates anoxia-induced down-regulation of FKBP12.6 and intracellular calcium handling dysfunction in H9c2 cells.
J. Mol. Cell. Cardiol. 80 , 166-74, (2015) Statins have beneficial pleiotropic effects beyond lipid lowering on the cardiovascular system. These cardio-protective effects are mediated through inhibition of the intracellular mevalonate pathway, by decreasing isoprenoid intermediate synthesis and the su... |
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The floral transcriptome of ylang ylang (Cananga odorata var. fruticosa) uncovers biosynthetic pathways for volatile organic compounds and a multifunctional and novel sesquiterpene synthase.
J. Exp. Bot. 66 , 3959-75, (2015) The pleasant fragrance of ylang ylang varieties (Cananga odorata) is mainly due to volatile organic compounds (VOCs) produced by the flowers. Floral scents are a key factor in plant-insect interactions and are vital for successful pollination. C. odorata var.... |
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Metabolic engineering of the Stevia rebaudiana ent-kaurene biosynthetic pathway in recombinant Escherichia coli.
J. Biotechnol. 214 , 95-102, (2015) The ent-kaurene is a dedicated precursor pool and is responsible for synthesizing natural sweeteners such as steviol glycosides. In this study, to produce ent-kaurene in Escherichia coli, we modularly constructed and expressed two ent-kaurene genes encoding e... |
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Bisphosphonate Induces Osteonecrosis of the Jaw in Diabetic Mice via NLRP3/Caspase-1-Dependent IL-1β Mechanism.
J. Bone Miner Res. 30 , 2300-12, (2016) Diabetes mellitus is an established risk factor associated with bisphosphonate-related osteonecrosis of the jaw (BRONJ). Sustained activation of Nod-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome contributes to the persiste... |
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Systems analysis of methylerythritol-phosphate pathway flux in E. coli: insights into the role of oxidative stress and the validity of lycopene as an isoprenoid reporter metabolite.
Microb. Cell Fact. 14(1) , 193, (2015) High-throughput screening methods assume that the output measured is representative of changes in metabolic flux toward the desired product and is not affected by secondary phenotypes. However, metabolic engineering can result in unintended phenotypes that ma... |
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Cloning and characterization of farnesyl pyrophosphate synthase from the highly branched isoprenoid producing diatom Rhizosolenia setigera.
Sci. Rep. 5 , 10246, (2015) The diatom Rhizosolenia setigera Brightwell produces highly branched isoprenoid (HBI) hydrocarbons that are ubiquitously present in marine environments. The hydrocarbon composition of R. setigera varies between C25 and C30 HBIs depending on the life cycle sta... |