13058-04-3
13058-04-3 structure
- Name: Farnesyl pyrophosphate
- Chemical Name: farnesyl diphosphate
- CAS Number: 13058-04-3
- Molecular Formula: C15H37N3O7P2
- Molecular Weight: 433.418
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2018-06-11 17:38:23
- Modify Date: 2024-01-03 23:29:21
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Farnesyl pyrophosphate, a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis[1].
| Name | farnesyl diphosphate |
|---|---|
| Synonyms |
MFCD00189688
FARNESYLPYROPHOSPHATE (2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl trihydrogen diphosphate triammoniate Farnesyl pyrophosphate ammonium salt Diphosphoric acid, (2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl ester, triammonium salt 3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl pyrophosphate ammonium salt FPP |
| Description | Farnesyl pyrophosphate, a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Farnesyl pyrophosphate 作为一种确定的危险信号，可触发急性细胞死亡，导致中风中的神经元丢失。Farnesyl pyrophosphate 含有疏水性 15 碳异戊二烯基链和带大量电荷的焦磷酸头部，导致急性细胞死亡，与其下游代谢途径无关。从机制上讲，细胞外钙流入和阳离子通道瞬时受体电位 melastatin 2 (TRPM2) 在 Farnesyl pyrophosphate 诱导的细胞死亡中发挥重要作用。Farnesyl pyrophosphate 酸激活 TRPM2 开放离子流入[1]。 |
| In Vivo | 就大脑中动脉闭塞（MCAO）构建的小鼠模型而言，Farnesyl pyrophosphate 在脑内蓄积，表明 Farnesyl pyrophosphate 和TRPM2危险信号轴在缺血性损伤中的作用。Farnesyl pyrophosphate/TRPM2 信号轴和 MVA 通路在脑缺血和潜在的神经退行性疾病中发挥重要作用[1]。 |
| References |
| Molecular Formula | C15H37N3O7P2 |
|---|---|
| Molecular Weight | 433.418 |
| Flash Point | 16 °C - closed cup (lit.) |
| Exact Mass | 433.210663 |
| PSA | 142.63000 |
| LogP | 5.60360 |
| Storage condition | 20°C |
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H315-H319-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378 |
| Hazard Codes | F;T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN 1230 3/PG 2 |
| HS Code | 2905290000 |
| HS Code | 2905290000 |
|---|---|
| Summary | 2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |