Rifamycin sodium
Rifamycin sodium structure
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Common Name | Rifamycin sodium | ||
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| CAS Number | 14897-39-3 | Molecular Weight | 719.750 | |
| Density | 1.35g/cm3 | Boiling Point | 862.1ºC at 760mmHg | |
| Molecular Formula | C37H46NNaO12 | Melting Point | >215°C (dec.) | |
| MSDS | Chinese USA | Flash Point | 475.2ºC | |
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Polyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition.
Nat. Prod. Rep. 31(4) , 504-13, (2014) Despite the longstanding importance of polyketide natural products in human medicine, nearly all commercial polyketide-based drugs are prepared through fermentation or semi-synthesis. The paucity of manufacturing routes involving de novo chemical synthesis re... |
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No impact of rifamycin selection on tuberculosis treatment outcome in HIV coinfected patients.
AIDS 27(3) , 481-4, (2013) Rifabutin has been substituted for rifampicin when treating tuberculosis (TB)/HIV coinfection. However, despite reports of anti-TB treatment failure and acquired rifamycin resistance, long-term clinical outcome data are lacking. Observational analyses perform... |
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Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (HepG2) in vitro.
J. Enzyme Inhib. Med. Chem. 25(5) , 715-9, (2010) Serum paraoxonase (aryldialkylphosphatase, EC 3.1.8.1., PON1) is an esterase protein synthesised by the liver and released into the serum, where it is associated with HDL lipoproteins. In this study, we have determined the in vitro effects of the following an... |
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Two genes, rif15 and rif16, of the rifamycin biosynthetic gene cluster in Amycolatopsis mediterranei likely encode a transketolase and a P450 monooxygenase, respectively, both essential for the conversion of rifamycin SV into B.
Acta Biochim. Biophys. Sin. (Shanghai) 43 , 948-956, (2011) Amycolatopsis mediterranei produces an important antibiotic rifamycin, the biosynthesis of which involves many unusual modifications. Previous work suggested a putative P450 enzyme encoded by rif16 within the rifamycin biosynthetic gene cluster (rif) was requ... |
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A rapid and sensitive HPLC-MS method for the detection of plasma and cellular rifampicin.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 857(1) , 76-82, (2007) Rifampicin is active against both intracellular and extracellular Mycobacterium tuberculosis. The ability to measure rifampicin drug concentrations in both plasma and in cells may be useful in evaluating the suitability of dosage regimens for populations and ... |
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Clinical efficacy of rifamycin SV combined with oxytetracycline in the treatment of caseous lymphadenitis in sheep.
Vet. Rec. 159(7) , 216-7, (2006)
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Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions.
Xenobiotica 40(1) , 24-37, (2010) Transporters are carrier proteins that may influence pharmacokinetic, pharmacodynamic, and toxicological characteristics of drugs. The development of validated in vitro transporter models is imperative to support regulatory submissions of drug candidates. Thi... |
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Systemic absorption of rifamycin SV MMX administered as modified-release tablets in healthy volunteers.
Antimicrob. Agents Chemother. 55(5) , 2122-8, (2011) The new oral 200-mg rifamycin SV MMX modified-release tablets, designed to deliver rifamycin SV directly into the colonic lumen, offer considerable advantages over the existing immediate-release antidiarrheic formulations. In two pharmacokinetics studies of h... |
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A complex role of Amycolatopsis mediterranei GlnR in nitrogen metabolism and related antibiotics production.
Arch. Microbiol. 188(1) , 89-96, (2007) Amycolatopsis, genus of a rare actinomycete, produces many clinically important antibiotics, such as rifamycin and vancomycin. Although GlnR of Amycolatopsis mediterranei is a direct activator of the glnA gene expression, the production of GlnR does not linea... |
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Identification and characterization of glnA promoter and its corresponding trans-regulatory protein GlnR in the rifamycin SV producing actinomycete, Amycolatopsis mediterranei U32.
Acta Biochim. Biophys. Sin. (Shanghai) 38(12) , 831-43, (2006) The genetic requirements for the transcription of glnA, encoding the major glutamine synthetase in a rifamycin SV-producing Amycolatopsis mediterranei strain, U32, were investigated. Primer extension experiments showed that the promoter of U32 glnA (pglnA) wa... |