AIDS 2013-01-28

No impact of rifamycin selection on tuberculosis treatment outcome in HIV coinfected patients.

Richa Singh, Neal Marshall, Colette J Smith, Carl J Reynolds, Ronan A Breen, Sanjay Bhagani, Ian Cropley, Susan Hopkins, Leonie Swaden, Margaret A Johnson, Marc C Lipman

Index: AIDS 27(3) , 481-4, (2013)

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Abstract

Rifabutin has been substituted for rifampicin when treating tuberculosis (TB)/HIV coinfection. However, despite reports of anti-TB treatment failure and acquired rifamycin resistance, long-term clinical outcome data are lacking. Observational analyses performed in a UK TB/HIV cohort demonstrated no difference in severe adverse events, anti-TB treatment completion, relapse frequency or subsequent rifamycin resistance when rifampicin and rifabutin were compared, using different combinations of antiretroviral therapy. Our data support the wider use of rifabutin in TB/HIV coinfection.