4-Methylpyrazole hydrochloride
4-Methylpyrazole hydrochloride structure
|
Common Name | 4-Methylpyrazole hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 56010-88-9 | Molecular Weight | 118.56500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C4H7ClN2 | Melting Point | 157-159 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Czech mass methanol outbreak 2012: epidemiology, challenges and clinical features.
Clin. Toxicol. (Phila.) 52(10) , 1013-24, (2014) Methanol poisonings occur frequently globally, but reports of larger outbreaks where complete clinical and laboratory data are reported remain scarce. The objective of the present study was to report the data from the mass methanol poisoning in the Czech Repu... |
|
|
Locally-generated acetaldehyde is involved in ethanol-mediated LTP inhibition in the hippocampus.
Neurosci. Lett. 537 , 40-3, (2013) Consistent with the ability of severe alcohol intoxication to impair memory, high concentrations of ethanol (60mM) acutely inhibit long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. To account for this, we hypothesized that local metabo... |
|
|
Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea.
Eur. J. Pediatr. 174(4) , 509-18, (2015) This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONME... |
|
|
Effect of 4-methylpyrazole on antioxidant enzyme status and lipid peroxidation in the liver of rats after exposure to ethylene glycol and ethyl alcohol.
Pharmacol. Rep. 64(6) , 1547-53, (2012) The aim of the conducted studies was to evaluate the effect of 4-methylpyrazole, increasingly used in detoxifying treatments after ethylene glycol poisoning, on the activity of some antioxidant enzymes and lipid peroxidation formation in the liver of rats aft... |
|
|
Management of unintentional methanol ingestions - kids aren't little adults?
Clin. Toxicol. (Phila.) 51(5) , 455, (2013)
|
|
|
Inhibition of CYP2E1 leads to decreased malondialdehyde-acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure.
Life Sci. 92(6-7) , 325-36, (2013) Ethanol metabolism leads to the formation of acetaldehyde and malondialdehyde. Acetaldehyde and malondialdehyde can together form malondialdehyde-acetaldehyde (MAA) adducts. The role of alcohol dehydrogenase (ADH) and cytochrome P4502E1 (CYP2E1) in the format... |
|
|
Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats.
Toxicol. Appl. Pharmacol. 279(1) , 43-52, (2014) The lipid peroxidation end-product 4-hydroxynonenal (4-HNE) is generated in tissues during oxidative stress. As a reactive aldehyde, it forms Michael adducts with nucleophiles, a process that disrupts cellular functioning. Liver, lung and brain are highly sen... |
|
|
Screening of the inhibitory effect of xenobiotics on alcohol metabolism using S9 rat liver fractions.
Toxicol. In Vitro 26(7) , 1177-80, (2012) The purpose of this work was to develop and optimize a simple and suitable method to detect the potential inhibitory effect of drugs and medicines on alcohol dehydrogenase (ADH) activity in order to evaluate the possible interactions between medicines and alc... |
|
|
Cost of hemodialysis versus fomepizole-only for treatment of ethylene glycol intoxication.
Clin. Toxicol. (Phila.) 51(3) , 188, (2013)
|
|
|
Detectable serum ethylene glycol levels after subcutaneous injection of antifreeze.
Clin. Toxicol. (Phila.) 51(9) , 908-9, (2013)
|