(r)-(-)-1-(1-naphthyl)ethyl isocyanate
(r)-(-)-1-(1-naphthyl)ethyl isocyanate structure
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Common Name | (r)-(-)-1-(1-naphthyl)ethyl isocyanate | ||
|---|---|---|---|---|
| CAS Number | 42340-98-7 | Molecular Weight | 197.23300 | |
| Density | 1.118 g/mL at 25 °C(lit.) | Boiling Point | 106-108 °C0.16 mm Hg(lit.) | |
| Molecular Formula | C13H11NO | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 200 °F | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Enantiomeric analysis of phenylpropanolamine in plasma via resolution of dinitrophenylurea derivatives on a high performance liquid chromatographic chiral stationary phase.
Biomed. Chromatogr. 5(1) , 43-6, (1991) Racemic phenylpropanolamine was resolved on a high performance liquid chromatographic (HPLC) chiral stationary phase (CSP) as the 3,5-dinitrophenyl ureide derivative. The CSP was prepared by a simple in situ procedure in which (R)-(1-naphthyl)ethyl isocyanate... |
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Stereospecific high-performance liquid chromatographic assay of sotalol in plasma.
Pharm. Res. 8(9) , 1195-8, (1991) A convenient high-performance liquid chromatographic (HPLC) assay was developed for determination of sotalol (STL) enantiomers in plasma. Following addition of the internal standard (IS; racemic atenolol), enantiomers of STL and IS were extracted using ethyl ... |
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Stereospecific high-performance liquid chromatographic determination of tocainide.
J. Chromatogr. A. 566(1) , 155-62, (1991) A sensitive high-performance liquid chromatographic assay was developed for the determination of tocainide enantiomers in plasma. Following extraction of tocainide from plasma, the enantiomers were derivatized with S-(+)-1-(1-naphthyl)ethylisocyanate. The res... |
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Enantioselective analysis of sotalol in plasma by reversed-phase high-performance liquid chromatography using diastereomeric derivatives.
J. Chromatogr. B, Biomed. Appl. 672(1) , 89-96, (1995) A procedure for the concurrent determination of the (+)- and (-)-enantiomers of sotalol in plasma using high-performance liquid chromatography of diastereomeric derivatives is described. Sotalol is extracted from a 0.5-ml aliquot of plasma at pH 9.3 using eth... |
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Chiral high-performance liquid chromatographic determination of oxprenolol in plasma.
J. Chromatogr. A. 621(2) , 225-9, (1993) A sensitive, stereospecific high-performance liquid chromatographic assay for oxprenolol enantiomers in rat plasma was developed, using a chiral derivatization agent. Racemic oxprenolol and the internal standard (racemic propranolol) are extracted with dichlo... |
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The stereospecific determination of fluoxetine and norfluoxetine enantiomers in human plasma by high-pressure liquid chromatography (HPLC) with fluorescence detection.
Pharm. Res. 8(12) , 1528-32, (1991) A quantitative method for the simultaneous HPLC resolution and detection of the enantiomers of (R,S) fluoxetine (F) and their metabolites (R,S) norfluoxetine (N) in human plasma has been developed. F is a serotonin uptake inhibitor used in the treatment of de... |
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The separation of D/L amino acid pairs by high-performance liquid chromatography after precolumn derivatization with optically active naphthylethyl isocyanate.
Anal. Biochem. 165(1) , 38-44, (1987) A method for determining the optical purity of amino acids using HPLC and precolumn derivatization is described. (+)-1-(1-Naphthyl)ethyl isocyanate reacts with racemic amino acids, in high yield, to form naphthylethyl carbamoyl derivatives. The resulting dias... |
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Simultaneous determination of nadolol enantiomers in human plasma by high-performance liquid chromatography using fluorescence detection.
Biomed. Chromatogr. 9(3) , 140-5, (1995) A high-performance liquid chromatographic assay is described for the separation and quantification of nadolol isomers in human plasma. The isomers were quantified using reverse-phase HPLC and fluorometric detection after derivatization with the chiral reagent... |
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[The separation of some racemic beta-blockers and alpha-sympathomimetics with HPLC following derivatization].
Pharmazie 46(6) , 432-4, (1991) Five beta-adrenergic blocking agents and two alpha-sympathicomimetics were separated after derivatization with (R)-(-)-1-(Naphth-1-yl)-ethylisocyanate (NEIC). For two of these analytes the separation was successful also after reaction with (R)-(+)-1-phenyleth... |
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W.H. Pirkle, M.S. Hoekstra
J. Org. Chem. 39 , 3904, (1974)
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