5-Methyl-1H-pyrazole-3-carboxylic acid
5-Methyl-1H-pyrazole-3-carboxylic acid structure
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Common Name | 5-Methyl-1H-pyrazole-3-carboxylic acid | ||
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| CAS Number | 402-61-9 | Molecular Weight | 126.11 | |
| Density | 1.404g/cm3 | Boiling Point | 388.8ºC at 760mmHg | |
| Molecular Formula | C5H6N2O2 | Melting Point | 241 °C | |
| MSDS | Chinese USA | Flash Point | 188.9ºC | |
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Changes in the plasma concentrations of D-kynurenine and kynurenic acid in rats after intraperitoneal administration of tryptophan enantiomers.
Chirality 22 , 901-916, (2010) An aqueous solution of enantiomerically pure tryptophan (Trp), namely, D-Trp or L-Trp (100 mg/kg), was administered intraperitoneally to male Sprague-Dawley rats. The time-course profiles of the rat plasma concentrations of D-kynurenine (KYN), L-KYN, and kynu... |
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A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.
J. Pharmacol. Exp. Ther. 336 , 282-293, (2011) We have found that mutation of D-amino acid oxidase (DAO) diminished formalin-induced tonic pain. The present research further studied the analgesic effects of a series of DAO inhibitors in this model. 5-Chlorobenzo[d]isoxazol-3-ol (CBIO), 4H-thieno[3,2-b]pyr... |
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In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties.
Eur. Neuropsychopharmacol. 18(3) , 200-14, (2008) Non-competitive N-methyl-d-aspartate (NMDA) blockers induce schizophrenic-like behavior in healthy volunteers and exacerbate symptomatology in schizophrenic patients. Hence, a compound able to enhance NMDA neurotransmission by increasing levels of d-serine, a... |
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Plasma prostaglandin levels in rats with diabetes mellitus and diabetic ketoacidosis.
Diabetes 31(11) , 994-1001, (1982)
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Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges.
Biochem. Pharmacol. 78(11) , 1360-5, (2009) Antipsychotics, the drugs used currently for the treatment of schizophrenia, produce their therapeutic effects via the blockade of dopamine receptors. These compounds are, however, limited in their therapeutic efficacy and have side effect liabilities that al... |
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[Salts of 5-methylpyrazole-3-carboxylic acid with basically substituted adenine derivatives. Identification and lipolysis inhibitory activity (author's transl)].
Arzneimittelforschung 31(12) , 2096-100, (1981) 5-Methylpyrazole-3-carboxylic acid forms salts with basically substituted adenine bases of type (4) or (5), which have significantly more lipolysis inhibitory activity than the free acid itself. The substance tested, 6-amino-9-[2-hydroxy-3-(N-methyl-N-2-hydro... |
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The development of tolerance to antilipolytic agents in rats.
Biochem. Pharmacol. 34(2) , 269-74, (1985) The development of tolerance to the action of certain antilipolytic agents has been investigated in vivo in rats. Tolerance to oral nicotinic acid developed during twice daily dosing for 4 days at 100 and 250 mg/kg but not at 10, 25 or 50 mg/kg. Tolerance ind... |
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Effects of adrenaline on ketogenesis from long- and medium-chain fatty acids in starved rats.
Biochem. J. 204(3) , 749-56, (1982) 1. Injection of adrenaline into 24 h-starved rats caused a 69% decrease in blood [ketone-body] (3-hydroxybutyrate plus acetoacetate), accompanied by a decreased [3-hydroxybutyrate]/[acetoacetate] ratio. Blood [glucose] and [lactate] increased, but [alanine] w... |
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The development of tolerance to antilipolytic agents by isolated rat adipocytes.
Biochem. Pharmacol. 34(2) , 275-9, (1985) Using an isolated rat epididymal adipocyte system we have studied the development of tolerance to and cross-tolerance between nicotinic acid, 5-methylpyrazole-3-carboxylic acid and pyridyl-3-tetrazole. Preincubating isolated adipocytes with any one of these c... |
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Effects of nutritional status and acute variation in substrate supply on cardiac and skeletal-muscle fructose 2,6-bisphosphate concentrations.
Biochem. J. 250(3) , 773-9, (1988) We examined the long-term effects of nutritional status and the acute effects of changes in exogenous carbohydrate- and lipid-substrate supply and utilization on fructose 2,6-bisphosphate (Fru-2,6-P2) concentrations in heart, gastrocnemius and soleus. Starvat... |