- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 5-Methyl-1H-pyrazole-3-carboxylic acid
- Price: ￥398.0/1g
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 5-Methyl-1H-pyrazole-3-carboxylic acid
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
402-61-9
402-61-9 structure
- Name: 5-Methyl-1H-pyrazole-3-carboxylic acid
- Chemical Name: 5-methyl-pyrazole-3-carboxylic acid
- CAS Number: 402-61-9
- Molecular Formula: C5H6N2O2
- Molecular Weight: 126.11
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-09-10 21:39:18
- Modify Date: 2024-01-02 19:19:34
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AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 μM and EC50 of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia[1].
| Name | 5-methyl-pyrazole-3-carboxylic acid |
|---|---|
| Synonyms |
5-Methyl-1H-pyrazole-3-carboxylic acid
MFCD00462235 3-Methyl-1H-pyrazole-5-carboxylic acid AS057278 5-Methylpyrazole-3-carboxylic acid MPC |
| Description | AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 μM and EC50 of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.91 μM (DAAO)[1] |
| In Vivo | AS057278 (PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage) normalizes phencyclidine (PCP)-induced prepulse inhibition[1]. AS057278 (10 mg/kg; PO and IV; single dosage) exhibits good pharmacokinetic effects[1]. Pharmacokinetic Parameters of AS057278 in male Sprague-Dawley rats[1]. IV (10 mg/kg) PO (10 mg/kg) C0 (ng/mL) 100,557.3 Cmax (ng/mL) 73,559.8 8088.8 tmax (h) 0.083 1 CZ (ng/mL) 26.8 40.5 tZ (h) 24 24 AUCZ (ng/mL·h) 45,596.2 18,254.4 λZ (h^-1) 0.124 0.096 AUC (ng/mL·h) 45,810.9 18,649.9 VZ (L/kg) 1.76 VSS (L/kg) 0.24 CL (L/kg/h) 0.22 MRT (h) 1.087 F 0.407 Animal Model: Males C57BL/6J mice[1] Dosage: 80 mg/kg, 20 mg/kg Administration: PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage Result: Normalized phencyclidine (PCP)-induced prepulse inhibition after acute (80 mg/kg) and chronic (20 mg/kg b.i.d.) oral administration in mice. Animal Model: Male Sprague-Dawley rats[1] Dosage: 10 mg/kg Administration: PO and IV; single dosage (Pharmacokinetics Analysis) Result: Exhibited good pharmacokinetic effect. |
| References |
| Density | 1.404g/cm3 |
|---|---|
| Boiling Point | 388.8ºC at 760mmHg |
| Melting Point | 241 °C |
| Molecular Formula | C5H6N2O2 |
| Molecular Weight | 126.11 |
| Flash Point | 188.9ºC |
| Exact Mass | 126.04300 |
| PSA | 65.98000 |
| LogP | 0.41630 |
| Index of Refraction | 1.595 |
| Storage condition | 2~8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UQ6407500 |
| HS Code | 2933199090 |
| Precursor 9 | |
|---|---|
| DownStream 10 | |
![N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3, 4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-ca rboxamide structure](https://www.chemsrc.com/caspic/296/1044586-68-6.png)
| HS Code | 2933199090 |
|---|---|
| Summary | 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |