3-(2-chlorophenothiazin-10-yl)-N-methylpropan-1-amine
3-(2-chlorophenothiazin-10-yl)-N-methylpropan-1-amine structure
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Common Name | 3-(2-chlorophenothiazin-10-yl)-N-methylpropan-1-amine | ||
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| CAS Number | 1225-64-5 | Molecular Weight | 304.83800 | |
| Density | 1.229g/cm3 | Boiling Point | 458.2ºC at 760mmHg | |
| Molecular Formula | C16H17ClN2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 230.9ºC | |
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Prediction of drug responses in schizophrenia: a method using a test dose of chlorpromazine.
Psychiatry Clin. Neurosci. 51(4) , 217-22, (1997) Thirty-seven newly admitted schizophrenic patients were treated with an open and flexible dosage of chlorpromazine for 3 months after receiving a test dose. Levels of chlorpromazine, demethylated chlorpromazine and chlorpromazine sulfoxide 3 h after the test ... |
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Concentrations of chlorpromazine and two of its active metabolites in plasma and cerebrospinal fluid of psychotic patients treated with fixed drug doses.
Psychopharmacology 73(1) , 55-62, (1981) Efforts to find a correlation between serum levels of chlorpromazine (CPZ) and clinical effect have been rather unsuccessful, which could be due to fluctuations of CPZ and CPZ metabolite levels during treatment, the complicated metabolism of CPZ, or to varyin... |
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[A microanalytical gas liquid chromatography method with a nitrogen-phosphorus detector in the assay of various psychotropic drugs of tricyclic structure and of their N-demethylated metabolites].
Boll. Soc. Ital. Biol. Sper. 60(9) , 1757-63, (1984) Nanogram amounts of chlorimipramine, chlorpromazine and their Nor1- and Nor2-metabolites were detected in plasma by GLC with nitrogen-sensitive detection. Two extraction procedures were compared. The use of Sep Pak C18 cartridges produced a higher degree of a... |
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[N-dealkylation of chlorimipramine and chlorpromazine in patients undergoing chronic treatment with both drugs: preliminary results].
Boll. Soc. Ital. Biol. Sper. 60(9) , 1727-33, (1984) Data obtained in this preliminary study show that in patients chronically treated either with Chlorimipramine (n = 6) or with Chlorpromazine (n = 2), significant amounts of the corresponding Nor1- and Nor2-metabolites were detected in plasma. The role of thes... |
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Relationships between drug concentrations in serum and CSF, clinical effects and monoaminergic variables in schizophrenic patients treated with sulpiride or chlorpromazine.
Acta Psychiatr. Scand. Suppl. 311 , 49-74, (1984) Schizophrenic patients were treated with fixed doses of sulpiride (800 mg) or chlorpromazine (400 mg) during eight weeks using a double-blind design. In order to examine relationships between pharmacokinetic, clinical and biochemical parameters in relation to... |
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[Dehalogenation and N-dealkylation of chlorpromazine in patients undergoing chronic treatment].
Boll. Soc. Ital. Biol. Sper. 61(8) , 1101-4, (1985)
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Isothermal gas chromatographic determination of nanogram amounts of chlorimipramine, chlorpromazine and their N-desmethyl metabolites in plasma using nitrogen-selective detection.
J. Chromatogr. A. 381(2) , 315-22, (1986) A gas chromatographic method using nitrogen-selective detection for the quantitative determination of nanogram amounts of chlorimipramine, chlorpromazine and their nor1 and nor2 derivatives in plasma is described. Derivatization with trifluoroacetic anhydride... |
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Effects of calcium and verapamil on normal and tumor murine leukocytes.
Res. Commun. Chem. Pathol. Pharmacol. 48(2) , 305-8, (1985) Although no differences in membrane stabilization by calcium were noted between leukemic (P-388) and normal murine leukocytes, tumor cells were shown to be more resistant to damage by ethanol but not by desmethylchlorpromazine. Furthermore, verapamil protecte... |
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Phenothiazine-binding and attachment sites of CAPP1-calmodulin.
Biochemistry 28(9) , 3750-7, (1989) In the presence of Ca2+ norchlorpromazine isothiocyanate forms a monocovalent complex with calmodulin: CAPP1-calmodulin (Newton et al, 1983). Trypsin digestion of [3H]CAPP1-calmodulin yields as the major radioactive peptide N epsilon-CAPP-Lys-Met-Lys, corresp... |
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Effect of storage on the plasma concentration of chlorpromazine and six of its metabolites.
Ther. Drug Monit. 13(4) , 350-5, (1991) The concentrations of chlorpromazine (CPZ) and six of its metabolites in patient plasma samples that had been stored for 24 h at -20 degrees C, for 1 week at -20 degrees C, and for 4 weeks at -70 degrees C were compared. The concentrations of CPZ and six of i... |