Bollettino della Societa italiana di biologia sperimentale 1984-09-30

[N-dealkylation of chlorimipramine and chlorpromazine in patients undergoing chronic treatment with both drugs: preliminary results].

G P Sgaragli, R Ninci, L Della Corte, R Borghesi, M Nardini, N Battistini

Index: Boll. Soc. Ital. Biol. Sper. 60(9) , 1727-33, (1984)

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Abstract

Data obtained in this preliminary study show that in patients chronically treated either with Chlorimipramine (n = 6) or with Chlorpromazine (n = 2), significant amounts of the corresponding Nor1- and Nor2-metabolites were detected in plasma. The role of these metabolites in the overall therapeutic effect is under investigation.