Bollettino della Societa italiana di biologia sperimentale 1984-09-30

[A microanalytical gas liquid chromatography method with a nitrogen-phosphorus detector in the assay of various psychotropic drugs of tricyclic structure and of their N-demethylated metabolites].

G P Sgaragli, L Della Corte, M G Giovannini, R Ninci, C Franco, M Nardini

Index: Boll. Soc. Ital. Biol. Sper. 60(9) , 1757-63, (1984)

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Abstract

Nanogram amounts of chlorimipramine, chlorpromazine and their Nor1- and Nor2-metabolites were detected in plasma by GLC with nitrogen-sensitive detection. Two extraction procedures were compared. The use of Sep Pak C18 cartridges produced a higher degree of accuracy and precision with significant time and materials saving, as compared to the use of organic solvents in a three steps extraction procedure.