ANA-12
ANA-12 structure
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Common Name | ANA-12 | ||
|---|---|---|---|---|
| CAS Number | 219766-25-3 | Molecular Weight | 407.48500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H21N3O3S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Epigenetic regulation of spinal cord gene expression controls opioid-induced hyperalgesia.
Mol. Pain 10 , 59, (2014) The long term use of opioids for the treatment of pain leads to a group of maladaptations which includes opioid-induced hyperalgesia (OIH). OIH typically resolves within few days after cessation of morphine treatment in mice but is prolonged for weeks if hist... |
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HBZ stimulates brain-derived neurotrophic factor/TrkB autocrine/paracrine signaling to promote survival of human T-cell leukemia virus type 1-Infected T cells.
J. Virol. 88(22) , 13482-94, (2014) Brain-derived neurotrophic factor (BDNF) is a neurotrophin that promotes neuronal proliferation, survival, and plasticity. These effects occur through autocrine and paracrine signaling events initiated by interactions between secreted BDNF and its high-affini... |
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7, 8-Dihydroxyflavone Protects an Endothelial Cell Line from H2O2 Damage.
PLoS ONE 10 , e0135345, (2015) 7, 8-dihydroxyflavone (7, 8-DHF), a selective agonist for TrkB receptors, has been well studied for its neurotrophic functions. However, its roles outside the neural tissues have scarcely been studied as yet. In this study, we investigated the protecting role... |
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Dopamine D3 receptor is necessary for ethanol consumption: an approach with buspirone.
Neuropsychopharmacology 39(8) , 2017-28, (2014) Mesolimbic dopamine (DA) controls drug- and alcohol-seeking behavior, but the role of specific DA receptor subtypes is unclear. We tested the hypothesis that D3R gene deletion or the D3R pharmacological blockade inhibits ethanol preference in mice. D3R-defici... |
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Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF in place preference acquisition.
Br. J. Pharmacol. 172 , 4970-84, (2015) The psychostimulant mephedrone is often consumed in combination with alcohol (EtOH). This kind of drug consumption during adolescence is a matter of concern.We studied, in adolescent CD-1 mice, whether EtOH could enhance the psychostimulant (locomotor acivity... |
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Role of TrkB during the postnatal development of the rat carotid body.
Respir. Physiol. Neurobiol. 219 , 18-24, (2015) Brain-derived neurotrophic factor (BDNF) supports innervation of the carotid body by neurons projecting from the petrosal ganglion. Although carotid body glomus cells also express TrkB, BDNF's high affinity receptor, the role of BDNF in carotid body growth an... |
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Neurotrophins are expressed in giant cell arteritis lesions and may contribute to vascular remodeling.
Arthritis. Res. Ther. 16(6) , 487, (2015) Giant cell arteritis (GCA) is characterized by intimal hyperplasia leading to ischaemic manifestations that involve large vessels. Neurotrophins (NTs) and their receptors (NTRs) are protein factors for growth, differentiation and survival of neurons. They are... |
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Fingolimod phosphate attenuates oligomeric amyloid β-induced neurotoxicity via increased brain-derived neurotrophic factor expression in neurons.
PLoS ONE 8(4) , e61988, (2013) The neurodegenerative processes that underlie Alzheimer's disease are mediated, in part, by soluble oligomeric amyloid β, a neurotoxic protein that inhibits hippocampal long-term potentiation, disrupts synaptic plasticity, and induces the production of reacti... |
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Blockade of BDNF signaling turns chemically-induced long-term potentiation into long-term depression.
Hippocampus , doi:10.1002/hipo.22144, (2013) Long-term potentiation (LTP) is accompanied by increased spine density and dimensions triggered by signaling cascades involving activation of the neurotrophin brain-derived neurotrophic factor (BDNF) and cytoskeleton remodeling. Chemically-induced long-term p... |
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Enriched Environment Attenuates Surgery-Induced Impairment of Learning, Memory, and Neurogenesis Possibly by Preserving BDNF Expression.
Mol. Neurobiol. 53 , 344-54, (2016) Postoperative cognitive dysfunction (POCD) is a significant clinical syndrome. Neurogenesis contributes to cognition. It is known that enriched environment (EE) enhances neurogenesis. We determined whether EE attenuated surgery-induced cognitive impairment an... |