ANA-12
Modify Date: 2024-01-02 21:53:49
ANA-12 structure
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Common Name | ANA-12 | ||
|---|---|---|---|---|
| CAS Number | 219766-25-3 | Molecular Weight | 407.48500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H21N3O3S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of ANA-12ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively. |
| Name | N-{2-[(2-Oxo-3-azepanyl)carbamoyl]phenyl}-1-benzothiophene-2-carb oxamide |
|---|---|
| Synonym | More Synonyms |
| Description | ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively. |
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| Related Catalog | |
| In Vitro | ANA-12 (10 nM) prevents BDNF-induced neurite outgrowth in the TrkB-expressing cells, and completely abolishes the effects of BDNF at concentrations up to 10-100 μM[1]. |
| In Vivo | ANA-12 (0.5 mg/kg, i.p.) partially inhibits the total endogenous TrkB activity in the whole brain of mice. ANA-12, injected in mice, demonstrates anxiolytic and antidepressive activities at 0.5 mg/kg. ANA-12 (0.5, 1.0, and 2.0 mg/kg) does not affect neuron survival[1]. ANA-12 (0.5 mg/kg) shows antidepressant effects in lipopolysaccharide (LPS)-induced depression-like behavior. ANA-12 (0.5 mg/kg) significantly attenuates an increased immobility time in depressed mice. In the TST, FST, and SPT, ANA-12 (0.5 mg/kg) does not show antidepressant-like effects in the control mice[2]. ANA-12 (0.5 mg/kg, i.p.) reverses the diminished self-administration of cocaine in CocSired rats[3]. |
| Animal Admin | On the day of injection, ketamine (ketamine hydrochloride, 10 mg/kg), 7,8-dihydroxyflavone (7,8-DHF; 10 mg/kg), and ANA-12, N2-(2-{[(2-oxoazepan-3-yl) amino]carbonyl}phenyl)benzo[b]thiophene-2-carboxamide (0.5 mg/kg) are prepared in vehicle of 17 % dimethyl sulfoxide (DMSO) in phosphate-buffered saline. The doses of ketamine (10 mg/kg), 7,8-DHF (10 mg/kg), and ANA-12 (0.5 mg/kg) are selected. All compounds are administered intraperitoneally (i.p.) to mice. |
| References |
| Molecular Formula | C22H21N3O3S |
|---|---|
| Molecular Weight | 407.48500 |
| Exact Mass | 407.13000 |
| PSA | 126.01000 |
| LogP | 4.78680 |
| Appearance of Characters | white to beige |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: ≥5mg/mL at 60°C |
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Epigenetic regulation of spinal cord gene expression controls opioid-induced hyperalgesia.
Mol. Pain 10 , 59, (2014) The long term use of opioids for the treatment of pain leads to a group of maladaptations which includes opioid-induced hyperalgesia (OIH). OIH typically resolves within few days after cessation of mo... |
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HBZ stimulates brain-derived neurotrophic factor/TrkB autocrine/paracrine signaling to promote survival of human T-cell leukemia virus type 1-Infected T cells.
J. Virol. 88(22) , 13482-94, (2014) Brain-derived neurotrophic factor (BDNF) is a neurotrophin that promotes neuronal proliferation, survival, and plasticity. These effects occur through autocrine and paracrine signaling events initiate... |
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7, 8-Dihydroxyflavone Protects an Endothelial Cell Line from H2O2 Damage.
PLoS ONE 10 , e0135345, (2015) 7, 8-dihydroxyflavone (7, 8-DHF), a selective agonist for TrkB receptors, has been well studied for its neurotrophic functions. However, its roles outside the neural tissues have scarcely been studied... |
| ANA-12 |