N-[2-[[(六氢-2-氧代-1H-氮杂卓-3-基)氨基]羰基]苯基]苯并[b]噻吩-2-甲酰胺

更新时间：2025-08-23 00:28:24

N-[2-[[(六氢-2-氧代-1H-氮杂卓-3-基)氨基]羰基]苯基]苯并[b]噻吩-2-甲酰胺结构式	常用名	N-[2-[[(六氢-2-氧代-1H-氮杂卓-3-基)氨基]羰基]苯基]苯并[b]噻吩-2-甲酰胺	英文名	ANA-12
	CAS号	219766-25-3	分子量	407.48500
	密度	N/A	沸点	N/A
	分子式	C₂₂H₂₁N₃O₃S	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS07	信号词	Warning

用途

ANA-12是有效,选择性的 TrkB 拮抗剂,对高亲和力和低亲和力位点的IC50 分别为45.6 nM和41.1 μM。

中文名	N-[2-[[(六氢-2-氧代-1H-氮杂卓-3-基)氨基]羰基]苯基]苯并[b]噻吩-2-甲酰胺
英文名	N-{2-[(2-Oxo-3-azepanyl)carbamoyl]phenyl}-1-benzothiophene-2-carb oxamide
英文别名	更多

描述	ANA-12是有效,选择性的 TrkB 拮抗剂,对高亲和力和低亲和力位点的IC50 分别为45.6 nM和41.1 μM。
相关类别	信号通路 >> 蛋白酪氨酸激酶 >> Trk Receptor 研究领域 >> 神经疾病
体外研究	ANA-12(10 nM)可阻止BDNF诱导的TrkB表达细胞中神经突向外生长,并在浓度高达10-100μM时完全消除BDNF的作用[1]。
体内研究	ANA-12(0.5mg/kg,ip)部分抑制小鼠全脑中的内源性TrkB活性。注射到小鼠体内的ANA-12表现出0.5mg/kg的抗焦虑和抗抑郁活性。 ANA-12(0.5,1.0和2.0 mg/kg)不影响神经元存活[1]。 ANA-12(0.5mg/kg)在脂多糖(LPS)诱导的抑郁样行为中显示出抗抑郁作用。 ANA-12(0.5mg/kg)显着减弱抑郁小鼠的不动时间增加。在TST,FST和SPT中,ANA-12(0.5mg/kg)在对照小鼠中不显示抗抑郁样作用[2]。 ANA-12(0.5 mg/kg,ip)可逆转CocSired大鼠中可卡因自我给药的减少[3]。
动物实验	在注射当天，氯胺酮（氯胺酮盐酸盐，10 mg / kg），7,8-二羟基黄酮（7,8-DHF; 10 mg / kg）和ANA-12，N2-（2 - {[（2-在磷酸盐缓冲盐水中的17％二甲基亚砜（DMSO）载体中制备氧代氮杂环庚烷-3-基）氨基]羰基}苯基）苯并[b]噻吩-2-甲酰胺（0.5mg / kg）。选择氯胺酮（10mg / kg），7,8-DHF（10mg / kg）和ANA-12（0.5mg / kg）的剂量。将所有化合物腹膜内（ip）给予小鼠。
参考文献	[1]. Cazorla M, et al. Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest. 2011 May;121(5):1846-57. [2]. Zhang JC, et al. Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression. Psychopharmacology (Berl). 2015 Dec;232(23):4325-35. [3]. Vassoler FM, et al. Epigenetic inheritance of a cocaine-resistance phenotype. Nat Neurosci. 2013 Jan;16(1):42-7. [4]. Fang X, et al. Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. Eur Arch Psychiatry Clin Neurosci. 2018 Jun 7.

分子式	C₂₂H₂₁N₃O₃S
分子量	407.48500
精确质量	407.13000
PSA	126.01000
LogP	4.78680
InChIKey	TUSCYCAIGRVBMD-UHFFFAOYSA-N
SMILES	O=C(Nc1ccccc1C(=O)NC1CCCCNC1=O)c1cc2ccccc2s1
外观性状	white to beige
储存条件	2-8°C
水溶解性	DMSO: ≥5mg/mL at 60°C

符号	GHS07
信号词	Warning
危害声明	H302
危害码 (欧洲)	Xn
风险声明 (欧洲)	22
危险品运输编码	NONH for all modes of transport

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ANA-12