Ro 41-0960
Ro 41-0960 structure
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Common Name | Ro 41-0960 | ||
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| CAS Number | 125628-97-9 | Molecular Weight | 277.20500 | |
| Density | 1.536g/cm3 | Boiling Point | 489.9ºC at 760 mmHg | |
| Molecular Formula | C13H8FNO5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 250.1ºC | |
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Organic cation transporter 3 contributes to norepinephrine uptake into perivascular adipose tissue.
Am. J. Physiol. Heart Circ. Physiol. 309 , H1904-14, (2015) Perivascular adipose tissue (PVAT) reduces vasoconstriction to norepinephrine (NE). A mechanism by which PVAT could function to reduce vascular contraction is by decreasing the amount of NE to which the vessel is exposed. PVATs from male Sprague-Dawley rats w... |
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Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.
J. Biol. Chem. 290 , 13992-4003, (2015) Neurotransmitter:sodium symporters (NSSs) terminate neurotransmission by Na(+)-dependent reuptake of released neurotransmitters. Previous studies suggested that Na(+)-binding reconfigures dynamically coupled structural elements in an allosteric interaction ne... |
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Elevated expression of catechol-O-methyltransferase is associated with labor and increased prostaglandin E2production by human fetal membranes
Am. J. Obstet. Gynecol. 201(5) , 496.e1-7, (2009) Objective The purpose of this study was to evaluate the expression and function of catechol-O-methyltransferase in human fetal membranes at term. |
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Dopamine is metabolised by different enzymes along the rat nephron.
Pflugers Arch. 450(3) , 185-91, (2005) The purpose of this study was to determine the basal levels of dopamine (DA) and to examine the enzymes involved in DA metabolism in different microdissected nephron segments from rat kidneys. Segments were incubated with DA (50 nM) or DA plus monoamine oxida... |
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Treatment with an inhibitor of catechol-O-methyltransferase activity reduces preterm birth and impedes cervical resistance to stretch in pregnant rats.
Reproduction 134(6) , 831-9, (2007) Catechol-O-methyltransferase (COMT) enzyme catalyzes the methylation of the 2- or 4-hydroxyestrogens to 2- or 4-methoxyestrogens. Both the hydroxyestrogens and methoxyestrogens have been shown to block or enhance the effects of estrogen respectively. Our obje... |
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Catechol-O-methyltransferase inhibition increases the uptake of 11C-3-(3,4-dihydroxyphenyl)-L-alanine in the rat pancreas.
Scand. J. Gastroenterol. 31(12) , 1216-22, (1996) The objective of the present investigation was to evaluate the uptake and metabolism of 3-(3,4-dihydroxyphenyl-L-alanine) (L-DOPA) in the rat pancreas.The procedure included intravenous injection of the positron-emitting radiotracer L-[beta-11C] DOPA (DOP) in... |
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A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases.
Anal. Biochem. 373(2) , 296-306, (2008) A high-throughput, competitive fluorescence polarization immunoassay has been developed for the detection of methyltransferase activity. The assay was designed to detect S-adenosylhomocysteine (AdoHcy), a product of all S-adenosylmethionine (AdoMet)-utilizing... |
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Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons.
Mol. Pharmacol. 57(3) , 589-94, (2000) Inhibition of catechol-O-methyltransferase (COMT; EC 2.1.1.6) is a new therapeutic strategy in the treatment of Parkinson's disease. However, nothing is known about the effects of COMT inhibition on levodopa (L-dopa)-induced toxicity in dopamine (DA) neurons.... |
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Effect of L-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats.
Clin. Neuropharmacol. 20(1) , 55-66, (1997) L-Dopa is the most effective drug known for the treatment of Parkinson's disease. However, the large doses required to treat this neurodegenerative disorder can significantly affect tissue concentrations of sulfur amino acid metabolites due to peripheral and ... |
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Towards non-surgical therapy for uterine fibroids: catechol-O-methyl transferase inhibitor shrinks uterine fibroid lesions in the Eker rat model.
Hum. Reprod. 26(11) , 3008-18, (2011) Uterine leiomyomas (fibroids) are the most common pelvic tumors in women. We assessed the potential therapeutic utility of Ro 41-0960, a synthetic catechol-O-methyl transferase inhibitor (COMTI), in the Eker rat.We randomized uterine fibroid-bearing Eker rats... |