Filipin complex
Filipin complex structure
|
Common Name | Filipin complex | ||
|---|---|---|---|---|
| CAS Number | 11078-21-0 | Molecular Weight | 654.82800 | |
| Density | 1.161 g/cm3 | Boiling Point | 913.9ºC at 760 mmHg | |
| Molecular Formula | C35H58O11(forFilipinIII) | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 279.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.
Autophagy 10(7) , 1241-55, (2014) Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazole, a traditional antifungal drug, has been identified as a ... |
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Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.
MBio 6 , e00565-15, (2015) Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus entry requirements of NPC1 in vitro, its roles in filovirus replication and pathogenesis in vivo remai... |
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Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.
Molecular Neurodegeneration 10 , 56, (2015) Insulin degrading enzyme (IDE) is a major protease of amyloid beta peptide (Aβ), a prominent toxic protein in Alzheimer's disease (AD) pathogenesis. Previous studies suggested that statins promote IDE secretion; however, the underlying mechanism is unknown, a... |
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Clathrin-mediated entry and cellular localization of chlorotoxin in human glioma.
Cancer Cell Int. 11 , 27, (2011) Chlorotoxin (TM601), a scorpion venom- derived 36-AA peptide, is an experimental drug against recurrent glioma with tumor specificity but unknown route of intracellular distribution. The aim of this study was to evaluate the route of entry and cellular locali... |
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Intracellular trafficking of hyaluronic acid-chitosan oligomer-based nanoparticles in cultured human ocular surface cells.
Mol. Vis. 17 , 279-90, (2011) Nanoparticles are a promising alternative for ocular drug delivery, and our group has proposed that they are especially suited for ocular mucosal disorders. The goal of the present study was to determine which internalization pathway is used by cornea-derived... |
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Hearing loss is an early consequence of Npc1 gene deletion in the mouse model of Niemann-Pick disease, type C.
J. Assoc. Res. Otolaryngol. 15(4) , 529-41, (2014) Niemann-Pick disease, type C1 (NPC1) is a rare lysosomal lipidosis that is most often the result of biallelic mutations in NPC1, and is characterized by a fatal neurological degeneration. The pathophysiology is complex, and the natural history of the disease ... |
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Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.
Brain 128 , 2654-64, (2005) The distribution and tempo of neuronal loss in Parkinson's disease correlates poorly with the characteristic and more widely spread intracellular changes associated with the disease process (Lewy bodies and Lewy neurites). To determine early intracellular cha... |
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The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1.
J. Cell Biol. 182 , 603-614, (2008) Spatial regulation is an important feature of signal specificity elicited by cytoplasmic tyrosine kinases of the Src family (SRC family protein tyrosine kinases [SFK]). Cholesterol-enriched membrane domains, such as caveolae, regulate association of SFK with ... |