11078-21-0

11078-21-0 structure

Name: Filipin complex
Chemical Name: Filipin complex from Streptomyces filipinensis
CAS Number: 11078-21-0
Molecular Formula: C₃₅H₅₈O₁₁(forFilipinIII)
Molecular Weight: 654.82800
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2018-02-17 08:00:00
Modify Date: 2024-01-02 13:26:10
Filipin, produced as a mixture of related compounds known as the filipin complex (filipins I-IV) in nature[1], is a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure. Filipin III is the major component of Filipin[2].

Name	Filipin complex from Streptomyces filipinensis
Synonyms	(3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,1 0,12,14,16,27-Octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethylo xacyclooctacosa-17,19,21,23,25-pentaen-2-one

Description	Filipin, produced as a mixture of related compounds known as the filipin complex (filipins I-IV) in nature[1], is a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure. Filipin III is the major component of Filipin[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Anti-infection >> Fungal
References	[1]. Kelly PM, et al. Separation of the filipin complex by gradient-elution high performance liquid chromatography. J Antibiot (Tokyo). 1985 Apr;38(4):485-9. [2]. Payero TD, et al. Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,215,1980

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xn: Harmful;Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport