3-hydroxy-dl-kynurenine
3-hydroxy-dl-kynurenine structure
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Common Name | 3-hydroxy-dl-kynurenine | ||
|---|---|---|---|---|
| CAS Number | 2147-61-7 | Molecular Weight | 224.21300 | |
| Density | 1.461g/cm3 | Boiling Point | 519.3ºC at 760 mmHg | |
| Molecular Formula | C10H12N2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 267.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes.
J. Nutr. 145(1) , 87-95, (2015) The use of oral contraceptives (OCs) has been associated with low plasma pyridoxal 5'-phosphate (PLP). The functional consequences are unclear.To determine whether functional vitamin B-6 insufficiency occurs in OC users and is attributable to OCs, we investig... |
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Manipulation with kynurenines: a possible tool for treating neurodegenerative diseases?
Expert Rev. Clin. Pharmacol. 5(4) , 351-3, (2012)
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Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.
J. Nutr. Sci. Vitaminol. 60(4) , 255-60, (2014) We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-control... |
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Behavioral Deficits Are Accompanied by Immunological and Neurochemical Changes in a Mouse Model for Neuropsychiatric Lupus (NP-SLE).
Int. J. Mol. Sci. 16 , 15150-71, (2015) Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) have been understudied compared to end-organ failure and peripheral pathology. Neuropsychiatric symptoms, particularly affective and cognitive indications, may be among the earliest manifestat... |
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Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.
Brain. Behav. Immun. 46 , 147-53, (2015) Chronic pain frequently co-occurs with major depressive disorder but the mechanisms are poorly understood. We investigated the contribution of indoleamine 2,3-dioxygenase-1 (IDO1), a rate-limiting enzyme in the conversion of tryptophan to neurotoxic metabolit... |
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A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma.
J. Pharm. Biomed. Anal. 107 , 426-31, (2015) Neuroactive metabolites in the kynurenine pathway of tryptophan catabolism are associated with neurodegenerative disorders. Tryptophan is transported across the blood-brain barrier and converted via the kynurenine pathway to N-formyl-L-kynurenine, which is fu... |
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Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency.
Sci. Rep. 5 , 11864, (2015) Serotonin is an important neurotransmitter that broadly participates in various biological processes. While serotonin deficiency has been associated with multiple pathological conditions such as depression, schizophrenia, Alzheimer's disease and Parkinson's d... |
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Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity.
J. Med. Chem. 52 , 389-96, (2009) Homo sapiens kynureninase is a pyridoxal-5'-phosphate dependent enzyme that catalyzes the hydrolytic cleavage of 3-hydroxykynurenine to yield 3-hydroxyanthranilate and L-alanine as part of the tryptophan catabolic pathway leading to the de novo biosynthesis o... |
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[Kynurenines in pathogenesis of endogenous psychiatric disorders].
Vestn. Ross. Akad. Med. Nauk (1) , 35-41, (2013) The essential amino acid tryptophan is metabolized on the methoxyindole pathway to serotonin, melatonin and 5-hydroxyindoleacetic acid and on the kynurenine pathway to kynurenine and related neuroactive metabolites, including 3-hydroxykynurenine, kynurenic ac... |
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A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Clin. Exp. Immunol. 173(1) , 121-30, (2013) Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation and serve as markers of cellular immune activation, but data are sparse on other determinants of these markers and metabolites of the kynurenine pathway. We measured neop... |