D,L-Buthionine-(S,R)-sulfoximine
D,L-Buthionine-(S,R)-sulfoximine structure
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Common Name | D,L-Buthionine-(S,R)-sulfoximine | ||
|---|---|---|---|---|
| CAS Number | 5072-26-4 | Molecular Weight | 222.30500 | |
| Density | 1.29g/cm3 | Boiling Point | 382.3ºC at 760 mmHg | |
| Molecular Formula | C8H18N2O3S | Melting Point | 215ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 185ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Redox regulation of MMP-3/TIMP-1 ratio in intestinal myofibroblasts: Effect of N-acetylcysteine and curcumin
Exp. Cell Res. 323(1) , 77-86, (2014) Matrix metalloproteinases (MMPs) play a critical role in inflammation and ulcerations in gut of Crohn׳s disease (CD) patients. Intestinal subepithelial myofibroblasts (ISEMFs) secrete MMPs in response to inflammatory stimuli. Previous data showed in CD-ISEMFs... |
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Inhibition of glutathione synthesis distinctly alters mitochondrial and cytosolic redox poise.
Exp. Biol. Med. (Maywood.) 239(4) , 394-403, (2014) The glutathione couple GSH/GSSG is the most abundant cellular redox buffer and is not at equilibrium among intracellular compartments. Perturbation of glutathione poise has been associated with tumorigenesis; however, due to analytical limitations, the underl... |
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Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine.
Chem. Biol. Interact. 225 , 13-20, (2015) Glycyrrhizae radix (G. radix) has been demonstrated to have hepatoprotective properties. This study determined the therapeutic effects of isoliquiritigenin (isoLQ) in G. radix, against liver injury induced by CCl4 in rats. CCl4 (0.5 ml/kg/d, twice) or CCl4 pl... |
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Grape powder supplementation prevents oxidative stress-induced anxiety-like behavior, memory impairment, and high blood pressure in rats.
J. Nutr. 143(6) , 835-42, (2013) We examined whether or not grape powder treatment ameliorates oxidative stress-induced anxiety-like behavior, memory impairment, and hypertension in rats. Oxidative stress in Sprague-Dawley rats was produced by using L-buthionine-(S,R)-sulfoximine (BSO). Four... |
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Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells.
Toxicol. Lett. 216(2-3) , 159-70, (2013) "Ecstasy" (3,4-methylenedioxymethamphetamine or MDMA) is a widely abused recreational drug, reported to produce neurotoxic effects, both in laboratory animals and in humans. MDMA metabolites can be major contributors for MDMA neurotoxicity. This work studied ... |
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A fluorescent probe for intracellular cysteine overcoming the interference by glutathione.
Org. Biomol. Chem. 12(32) , 6128-33, (2014) Cysteine (Cys) plays important roles in many physiological processes of eukaryotic cells and its detection in cells is of fundamental significance. However, glutathione (GSH), homocysteine, N-acetyl-L-cysteine and other thiols greatly hamper the detection of ... |
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Implication of glutathione in the in vitro antiplasmodial mechanism of action of ellagic acid.
PLoS ONE 7(9) , e45906, (2012) The search for new antimalarial chemotherapy has become increasingly urgent due to parasite resistance to current drugs. Ellagic acid (EA) is a polyphenol, recently found in various plant products, that has effective antimalarial activity in vitro and in vivo... |
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Cellular accumulation of Cys326-OGG1 protein complexes under conditions of oxidative stress.
Biochem. Biophys. Res. Commun. 447(1) , 12-8, (2014) The common Ser326Cys polymorphism in the base excision repair protein 8-oxoguanine glycosylase 1 is associated with a reduced capacity to repair oxidative DNA damage particularly under conditions of intracellular oxidative stress and there is evidence that Cy... |
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Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to D-lactate.
Exp. Biol. Med. (Maywood.) 238(4) , 360-9, (2013) Methylglyoxal (MGO) is a dicarbonyl that reacts with amino acids and nucleic acids to form advanced glycation endproducts, which may contribute to diabetes and its cardiovascular complications. MGO detoxification through the glyoxalase (GLO) pathway is glutat... |
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Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes.
Int. J. Biochem. Cell Biol. 44(12) , 2106-15, (2012) Previously we reported that the sesquiterpene lactone parthenolide induces oxidative stress in cardiac myocytes, which blocks Janus kinase (JAK) activation by the interleukin 6 (IL-6)-type cytokines. One implication suggested by this finding is that IL-6 sign... |