DC Chemicals Limited
China
Product Name: D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine)
Price: $100.0/100mg $200.0/250mg $400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Butanoic acid,2-amino-4-(S-butylsulfonimidoyl)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

5072-26-4

5072-26-4 structure

5072-26-4 structure

Name: D,L-Buthionine-(S,R)-sulfoximine
Chemical Name: S-butyl-DL-homocysteine (S,R)-sulfoximine
CAS Number: 5072-26-4
Molecular Formula: C₈H₁₈N₂O₃S
Molecular Weight: 222.30500
Catalog: Research Areas Cancer
Create Date: 2019-01-25 21:58:11
Modify Date: 2024-01-02 21:49:09
D,L-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

Name	S-butyl-DL-homocysteine (S,R)-sulfoximine
Synonyms	2-amino-4-(butylsulfonimidoyl)butanoic acid DL-Buthionine (S,R)-sulfoximine EINECS 246-685-1 MFCD00070309 D,L-Buthionine-(S,R)-sulfoximine

Description	D,L-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
Target	glutamylcysteine synthetase[1]
In Vitro	Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine[1].
In Vivo	Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors[2].
Animal Admin	Mice[2] D,L-Buthionine-(S,R)-sulfoximine is dissolved in sterile 0.9% saline, filtered through a 0.2-p.m polysulfone membrane filter, and administered by 48-h continuous iv. infusion at a dose of 300 mg/kg/day and 600 mg/kg/day starting at 24 h before doxorubicin administration. In vivo GSH levels after treatment with D,L-Buthionine-(S,R)-sulfoximine at a dose of 300 mg/kg and 600 mg/kg for 24 h as an iv. continuous infusion in munine plasma and in tumor tissue of HT1080 and HT1080/DR4 xenografts is measured[2].
References	[1]. Griffith OW, et al. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 1979 Aug 25;254(16):7558-60. [2]. Vanhoefer U, et al. d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin Cancer Res. 1996 Dec;2(12):1961-8.

Density	1.29g/cm3
Boiling Point	382.3ºC at 760 mmHg
Melting Point	215ºC (dec.)(lit.)
Molecular Formula	C₈H₁₈N₂O₃S
Molecular Weight	222.30500
Flash Point	185ºC
Exact Mass	222.10400
PSA	112.62000
LogP	2.30100
Index of Refraction	1.537
Storage condition	2-8°C
Water Solubility	H2O: 50 mg/mL, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7713435

CHEMICAL NAME :: Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-

CAS REGISTRY NUMBER :: 5072-26-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H18-N2-O3-S

MOLECULAR WEIGHT :: 222.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1 gm/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - other effects

REFERENCE :: REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,133,1992

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	EK7713435