Estrone sulfate sodium
Estrone sulfate sodium structure
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Common Name | Estrone sulfate sodium | ||
|---|---|---|---|---|
| CAS Number | 438-67-5 | Molecular Weight | 372.41 | |
| Density | 1.349 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H21NaO5S | Melting Point | 258-260°C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.
J. Pharm. Sci. 102(1) , 280-8, (2013) We aimed to explore the major active components in grapefruit juice (GFJ), orange juice (OJ), and apple juice (AJ) that are responsible for OATP2B1-mediated drug interactions, by means of in vitro studies using Xenopus oocytes expressing OATP2B1 with a typica... |
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Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship.
Drug Metab. Dispos. 43(2) , 284-8, (2015) To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell lines (overexpressing the transporter) and then scale these t... |
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Inclusion of endogenous hormone levels in risk prediction models of postmenopausal breast cancer.
J. Clin. Oncol. 32(28) , 3111-7, (2014) Endogenous hormones are risk factors for postmenopausal breast cancer, and their measurement may improve our ability to identify high-risk women. Therefore, we evaluated whether inclusion of plasma estradiol, estrone, estrone sulfate, testosterone, dehydroepi... |
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Prediction of the in vivo OATP1B1-mediated drug-drug interaction potential of an investigational drug against a range of statins.
Eur. J. Pharm. Sci. 47(1) , 244-55, (2012) To support drug development, the drug-drug interaction potential (DDI) of an investigational drug (AZX) was assessed against the probe estradiol 17β-glucuronide as well as against simvastatin acid, atorvastatin, pravastatin, pitavastatin, fluvastatin, rosuvas... |
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Relationship of body mass index with aromatisation and plasma and tissue oestrogen levels in postmenopausal breast cancer patients treated with aromatase inhibitors.
Eur. J. Cancer 50(6) , 1055-64, (2014) Recent data have raised concern about the clinical efficacy of aromatase inhibitors in overweight and/or obese breast cancer patients. We report in vivo aromatase inhibition and plasma and tissue oestrogen levels in relation to body mass index (BMI) status am... |
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Identification of multiple binding sites for substrate transport in bovine organic anion transporting polypeptide 1a2.
Drug Metab. Dispos. 41(3) , 602-7, (2013) Organic anion transporting polypeptides (OATP) have been extensively recognized as key determinants of absorption, distribution, metabolism, and excretion of various drugs because of their broad substrate specificity, wide tissue distribution, and the involve... |
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Active sulforhodamine 101 uptake into hippocampal astrocytes.
PLoS ONE 7(11) , e49398, (2012) Sulforhodamine 101 (SR101) is widely used as a marker of astrocytes. In this study we investigated labeling of astrocytes by SR101 in acute slices from the ventrolateral medulla and the hippocampus of transgenic mice expressing EGFP under the control of the a... |
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Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption.
Drug Metab. Dispos. 41(3) , 615-21, (2013) Enzyme-based grapefruit juice (GFJ)-drug interactions are mainly due to mechanism-based irreversible inhibition of metabolizing enzyme CYP3A4 by GFJ components, but the transporter organic anion transporting polypeptide (OATP)2B1 is also a putative site of in... |
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α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4).
Pflugers Arch. 464(4) , 367-74, (2012) 2-Oxoglutarate or α-ketoglutarate (αKG) is a substrate of HIF prolyl hydroxylases 1-3 that decrease cellular levels of the hypoxia-inducible factor 1α (HIF-1α) in the presence of oxygen. αKG analogs are applied to stabilize HIF-1α even in the presence of oxyg... |
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Estrone sulfate source of estrone and estradiol formation in isolated human hair roots: identification of a pathway linked to hair growth phase and subject to site-, gender-, and age-related modulations.
J. Clin. Endocrinol. Metab. 99(4) , 1393-9, (2014) The present study investigated the metabolism of estrone sulfate into bioactive estrogens in the human hair root, including the effects of hair growth phase, anatomical site, gender, and age.Healthy male (n = 18) and female (n = 20) subjects were investigated... |