3-Chloro-L-Alanine Hydrochloride
3-Chloro-L-Alanine Hydrochloride structure
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Common Name | 3-Chloro-L-Alanine Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 51887-89-9 | Molecular Weight | 159.999 | |
| Density | 1.401g/cm3 | Boiling Point | 243.6ºC at 760mmHg | |
| Molecular Formula | C3H7Cl2NO2 | Melting Point | 205 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 101.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling.
Nat. Commun. 6 , 6693, (2015) Skeletal muscle has a pleiotropic role in organismal energy metabolism, for example, by storing protein as an energy source, or by excreting endocrine hormones. Muscle proteolysis is tightly controlled by the hypothalamus-pituitary-adrenal signalling axis via... |
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[Regulation of key enzymes of L-alanine biosynthesis by Brevibacterium flavum producer strains].
Prikl. Biokhim. Mikrobiol. 49(2) , 144-8, (2013) The mechanisms of L-alanine overproduction by Brevibacterium flavum producer strains were studied. It was shown that beta-CI-L-alanine is an inhibitor of some key enzymes involved in the synthesis of L-alanine, including alanine transaminase and valine-pyruva... |
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Structural and mutational studies on substrate specificity and catalysis of Salmonella typhimurium D-cysteine desulfhydrase.
PLoS ONE 7(5) , e36267, (2012) Salmonella typhimurium DCyD (StDCyD) is a fold type II pyridoxal 5' phosphate (PLP)-dependent enzyme that catalyzes the degradation of D-Cys to H(2)S and pyruvate. It also efficiently degrades β-chloro-D-alanine (βCDA). D-Ser is a poor substrate while the enz... |
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Inositol phosphoceramide synthase is a regulator of intracellular levels of diacylglycerol and ceramide during the G1 to S transition in Saccharomyces cerevisiae.
Biochem. J. 388(Pt 1) , 169-76, (2005) We recently reported that DAG (diacylglycerol) generated during sphingomyelin synthesis plays an important role in protein kinase C activation and cell proliferation in Madin-Darby canine kidney cells [Cerbon and Lopez-Sanchez (2003) Biochem. J. 373, 917-924]... |
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Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn.
Arch. Biochem. Biophys. 415(2) , 184-92, (2003) Sphinganine and 4-hydroxysphinganine (phytosphingosine) are the predominant free long-chain bases in lipid extracts of plant tissues. While the synthesis of sphinganine in plants has been investigated, the metabolic origin of 4-hydroxysphinganine is not known... |
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Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: insight into the mechanism of a unique pyridoxal-5'-phosphate dependent cyclopropane ring-opening reaction.
Biochemistry 43(42) , 13328-39, (2004) 1-Aminocyclopropane-1-carboxylate (ACC) deaminase is a pyridoxal 5'-phosphate (PLP) dependent enzyme catalyzing the opening of the cyclopropane ring of ACC to give alpha-ketobutyric acid and ammonia as the products. This ring cleavage reaction is unusual beca... |
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Role of sphingosine synthesis inhibition in transcutaneous delivery of levodopa.
Int. J. Pharm. 238(1-2) , 43-50, (2002) The present study was designed to investigate the role of skin sphingosine synthesis inhibition in enhancing the in vitro permeation of levodopa (LD), a hydrophilic drug, across rat skin. beta-Chloroalanine (beta-CA), a selective inhibitor of serine palmitoyl... |
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Stereochemistry of reactions of the inhibitor/substrates L- and D-beta-chloroalanine with beta-mercaptoethanol catalysed by L-aspartate aminotransferase and D-amino acid aminotransferase respectively.
Org. Biomol. Chem. 3(18) , 3357-64, (2005) Two members of the alpha-family of PLP-dependent enzymes, L-aspartate aminotransferase and D-amino acid aminotransferase, have been shown to catalyse beta-substitution of L- and D-beta-chloroalanine respectively with beta-mercaptoethanol, reactions typical of... |
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Reactions of human liver peroxisomal alanine:glyoxylate aminotransferase with beta-chloro-L-alanine and L-cysteine: spectroscopic and kinetic analysis.
Biochim. Biophys. Acta 1784(9) , 1356-62, (2008) In addition to the main transaminase reaction, the pyridoxal 5'-phosphate-dependent enzyme human liver peroxisomal alanine:glyoxylate aminotransferase (AGT) is able to catalyze the alpha,beta-elimination of beta-chloro-L-alanine with a catalytic efficiency si... |