Ac-muramyl-Ala-D-Glu-NH2
Ac-muramyl-Ala-D-Glu-NH2 structure
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Common Name | Ac-muramyl-Ala-D-Glu-NH2 | ||
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| CAS Number | 53678-77-6 | Molecular Weight | 492.478 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 1023.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C19H32N4O11 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 572.9±34.3 °C | |
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Enhanced anti-tumor immune responses and delay of tumor development in human epidermal growth factor receptor 2 mice immunized with an immunostimulatory peptide in poly(D,L-lactic-co-glycolic) acid nanoparticles.
Breast Cancer Res. 17 , 48, (2015) Cancer vaccines have the potential to induce curative anti-tumor immune responses and better adjuvants may improve vaccine efficacy. We have previously shown that Hp91, a peptide derived from the B box domain in high-mobility group box protein 1 (HMGB1), acts... |
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The crosstalk between TLR2 and NOD2 in Aspergillus fumigatus keratitis.
Mol. Immunol. 64(2) , 235-43, (2015) Innate immunity is considered to be critical in the pathogenesis of fungal keratitis. Pattern recognition receptors (PRRs) recognize conserved microbial structures called pathogen-associated molecular patterns (PAMPS), thereby initiating the innate immunity. ... |
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Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.
Immunity 37(2) , 326-38, (2012) The intracellular sensor NOD1 has important host-defense functions relating to a variety of pathogens. Here, we showed that this molecule also participates in the induction of a noninfectious pancreatitis via its response to commensal organisms. Pancreatitis ... |
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Mifamurtide in metastatic and recurrent osteosarcoma: a patient access study with pharmacokinetic, pharmacodynamic, and safety assessments.
Pediatr. Blood Cancer 61(2) , 238-44, (2014) This non-randomized, patient-access protocol, assessed both safety and efficacy outcomes following liposomal muramyl-tripeptide-phosphatidylethanolamine (L-MTP-PE; mifamurtide) in patients with high-risk, recurrent and/or metastatic osteosarcoma.Patients rece... |
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Mifamurtide for high-grade, resectable, nonmetastatic osteosarcoma following surgical resection: a cost-effectiveness analysis.
Value Health 16(8) , 1123-32, (2013) Mifamurtide is an immune macrophage stimulant that when added to standard chemotherapy has demonstrated survival benefit for newly diagnosed osteosarcoma. The objectives of this study were to investigate the cost-effectiveness of adding mifamurtide to standar... |
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Cutting edge: New chimeric NOD2/TLR2 adjuvant drastically increases vaccine immunogenicity.
J. Immunol. 193(12) , 5781-5, (2014) TLR ligands are critical activators of innate immunity and are being developed as vaccine adjuvants. However, their usefulness in conjunction with NOD-like receptor agonists remains poorly studied. In this study, we evaluated a new ligand that targets both TL... |
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Recognition of Streptococcus pneumoniae and muramyl dipeptide by NOD2 results in potent induction of MMP-9, which can be controlled by lipopolysaccharide stimulation.
Infect. Immun. 82(12) , 4952-8, (2014) Matrix metallopeptidase 9 (MMP-9) is a protease involved in the degradation of extracellular matrix collagen. Evidence suggests that MMP-9 is involved in pathogenesis during Streptococcus pneumoniae infection. However, not much is known about the induction of... |
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[Induction and protective properties of antibodies against muramyl peptides of gram-negative bacteria].
Zh. Mikrobiol. Epidemiol. Immunobiol. (2) , 64-73, (2013) Characterize the role of humoral immune response in mechanisms of action of muramyl dipeptide immune stimulators.Mice were immunized by a complex of muramyl peptides (CMP) obtained from Salmonella typhi peptidoglycan and consisting of 3 components: 1) N-acety... |
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RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition.
Proc. Natl. Acad. Sci. U. S. A. 109(52) , 21426-31, (2012) The intracellular nucleotide-binding oligomerization domain-2 (NOD2) receptor detects bacteria-derived muramyl dipeptide (MDP) and activates the transcription factor NF-κB. Here we describe the regulatome of NOD2 signaling using a systematic RNAi screen. Usin... |
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Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond.
Cell. Mol. Life Sci. 70(18) , 3391-404, (2013) Crohn's disease (CD) is one of main disease entities under the umbrella term chronic inflammatory bowel disease. The etiology of CD involves alterations in genetic, microbiological, and immunological factors. This review is devoted to the role of the bacteria... |